ArticleBiochemistry research international2015
Comparative In Vitro Binding Studies of TiCl2(dpme)2, Ti(ada)2(bzac)2, and TiCl2(bzac)(bpme) Titanium Complexes with Calf-Thymus DNA.
Article in Biochemistry research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The binding of TiCl2(dpme)2 (1), (dpme = 6,6'-dimethyl-2,2'-bipyridine), Ti(ada)2(bzac)2 (2), (ada = adamantylamine; bzac = benzoylacetone), and TiCl2(bzac)(bpme) (3), (bpme = 4,4'-dimethyl-2,2'-bipyrdine) with calf thymus (ct) DNA has been studied by UV-visible spectroscopy, thermal denaturation, and circular dichroism spectroscopy. In UV-visible study complexes 1, 2, and 3 showed red, blue, and red shifts, respectively, upon the addition of ct-DNA along with a significant hyperchromism. The intrinsic binding constants (K b ) calculated from UV-visible absorption studies were 2.3 × 10(3) M(-1), 3.3 × 10(3) M(-1) and, 7.1 × 10(3) M(-1) for complexes 1, 2, and 3, respectively. The change in melting temperature (ΔT m ) was calculated to be 2-3°C for each complex. Circular dichroism (CD) study showed blue shift for complex 2 and red shift for complexes 1 and 3 along with rise in molecular ellipticity upon the addition of complexes. Results suggest a binding mode of complex 2 different than 1 and 3.
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