Evidence map›Paper›PMID 26843919›Full record

ArticleWorld journal of gastrointestinal surgery2016

Successful living donor intestinal transplantation in cross-match positive recipients: Initial experience.

Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Elisabeth Hetterman, Jose Oberholzer, Enrico Benedetti

Abstract readCase Reports
In one paragraph

Article in World journal of gastrointestinal surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Chimerism-Mediated Tolerance in Intestinal Transplantation.Gastroenterology clinics of North America · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raquel Garcia-RocaRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
Ivo G TzvetanovRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
Hoonbae JeonRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
Elisabeth HettermanRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
Jose OberholzerRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
Enrico BenedettiRaquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensitized patients tend to have longer waiting times on the deceased donor list and are at increased risk of graft loss from acute or chronic rejection compared to non-sensitized candidates. Desensitization protocols are utilized to decrease the levels of alloantibodies and to convert an initial positive cross-match to prospective donors into a negative crossmatch. These procedures are mostly available in the setting of living donation. Due to the elective nature of the procedure, desensitization protocols can be extended until the desire result is obtained prior to transplantation. We present two cases of successful desensitization protocol applied to living donor intestinal transplant candidates that converted to negative cross-match to their donors. We present two cases of intestinal transplant candidates with a potential living donor to whom they are sensitized. Both cases underwent successful transplantation after desensitization protocol. No evidence of humoral rejection has occurred in either recipient. Living donor intestinal transplantation in sensitized recipients against the prospective donors provides the ability to implement a desensitization protocol to convert to negative cross-match.

Indexed as

Desensitization protocolDonor specific antibodyIntestinal transplantLiving donorPlasmapheresisPositive crossmatch

Identifiers

PMID26843919
PMCPMC4724584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.