ArticleJournal of ginseng research2016
Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression.
Article in Journal of ginseng research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The roles of ginseng and ginsenosides for immune regulation: Relation to immunometabolic responses.Journal of ginseng research · 2026Review
- Ginseng Tea Consumption and Liver Cancer Risk: A Prospective Korean Multi-center Cancer Cohort Study.Journal of cancer prevention · 2026Article
- Korean Red Ginseng Polysaccharides Enhance Intestinal IgA Production and Barrier Function via Peyer's Patch Activation in Mice.Nutrients · 2024Article
- Experimental trials to assess the immune modulatory influence of thyme and ginseng oil on NDV-vaccinated broiler chickens.Open veterinary journal · 2024Article
- Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review.Journal of ginseng research · 2023Review
- Ginseng, a promising choice for SARS-COV-2: A mini review.Journal of ginseng research · 2022Review
- The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.Inflammopharmacology · 2022Review
- Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis.Journal of ginseng research · 2022Article
- Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function.Journal of ginseng research · 2021Article
- Effect of Modified Xijiao Dihuang Decoction () on Intestinal Flora and Th17/Treg in Rats with Radiation Enteritis.Chinese journal of integrative medicine · 2021Article
- Adaptogenic effects ofJournal of ginseng research · 2021Review
- Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial.Journal of ginseng research · 2021Article
- The safety, immunological benefits, and efficacy of ginseng in organ transplantation.Journal of ginseng research · 2020Review
- A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3.Biomolecules · 2020Article
- Review
- A Comparative Study on the Effects of Different Parts ofMolecules (Basel, Switzerland) · 2019Article
- A comparative study on immune-stimulatory and antioxidant activities of various types of ginseng extracts in murine and rodent models.Journal of ginseng research · 2018Article
- Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Effect of Korean Red Ginseng in chronic liver disease.Journal of ginseng research · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is not clear whether ginseng affects cyclosporine A (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA.
methodsUsing CD4+ T cells from mouse spleens stimulated with the T cell receptor (TCR) or allogeneic antigen-presenting cells (APCs), we examined the differentiation of naïve T cells into T helper 1 (Th1), Th2, Th17, and regulatory T cells (Tregs), and their cytokine production during treatment by Korean Red Ginseng extract (KRGE) and/or CsA. The influence of KRGE on the allogeneic T cell response was evaluated by mixed lymphocyte reaction (MLR). We also evaluated whether signal transducer and activator of transcription 3 (STAT3) and STAT5 are implicated in this regulation.
resultsUnder TCR stimulation, KRGE treatment did not affect the population of CD4+interferon gamma (IFNγ)+ and CD4+interleukin (IL)-4+ cells and their cytokine production compared with CsA alone. Under the Th17-polarizing condition, KRGE significantly reduced the number of CD4+IL-17+ cells and CD4+/phosphorylated STAT3 (p-STAT3)+ cells, but increased the number of CD4+CD25+forkhead box P3 (Foxp3)+ cells and CD4+/p-STAT5+ cells compared with CsA alone. In allogeneic APCs-stimulated CD4+ T cells, KRGE significantly decreased total allogeneic T cell proliferation. Consistent with the effects of TCR stimulation, KRGE reduced the number of CD4+IL-17+ cells and increased the number of CD4+CD25+Foxp3+ cells under the Th17-polarizing condition.
conclusionKRGE has immunological benefits through the reciprocal regulation of Th17 and Treg cells during CsA-induced immunosuppression.
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