ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2015
Genetic Profile of Patients with Familial Mediterranean Fever (FMF): Single Center Experience at King Hussein Medical Center (KHMC).
Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Clinico-demographic and molecular characteristics of familial Mediterranean fever in Egypt: a multicenter study.Scientific reports · 2026Article
- Updates on the molecular spectrum ofFrontiers in genetics · 2024Article
- Phenotype-genotype correlation in children with familial Mediterranean fever in Morocco.Qatar medical journal · 2024Article
- Heterozygous MEFV Mutation Leading to Renal Failure: A Case Study.Global pediatric health · 2024Article
- Genotype Mutations in Palestinian Children with Familial Mediterranean Fever: Clinical Profile, and Response to Colchicine Treatment: A Retrospective Cohort Study.Mediterranean journal of rheumatology · 2023Article
- Spectrum of auto-inflammatory diseases in Morocco: a monocentric experience.Rheumatology advances in practice · 2023Article
- Genotype-phenotype associations in familial Mediterranean fever: a study of 500 Egyptian pediatric patients.Clinical rheumatology · 2022Article
- Sequence analysis in Familial Mediterranean Fever patients with no confirmatory genotype.Rheumatology international · 2022Article
- Frequencies of theBalkan journal of medical genetics : BJMG · 2021Article
- Spectrum ofMedical sciences (Basel, Switzerland) · 2020Article
- Pattern and diagnostic evaluation of systemic autoinflammatory diseases other than familial Mediterranean fever among Arab children: a multicenter study from the Pediatric Rheumatology Arab Group (PRAG).Rheumatology international · 2020Article
- Familial Mediterranean Fever in Chinese Children: A Case Series.Frontiers in pediatrics · 2019Article
- Familial Mediterranean fever in Jordanian Children: single centre experience.Mediterranean journal of rheumatology · 2018Article
- Evaluation of subclinical inflammation in familial Mediterranean fever patients: relations with mutation types and attack status: a retrospective study.Clinical rheumatology · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the spectrum of genetic mutations in patients with clinical diagnosis of Familial Mediterranean Fever.
methodThis is a retrospective study of 3359 sera samples for patient with clinical diagnosis of FMF, over a period of 6 years. The samples were tested for 12 mutations of the MEFV gene by PCR& hybridization of the PCR product with Probes immobilized as an array of panel lines.
resultsA total of 1868 (55.6%) samples were found negative, and one or more mutations were detected in 1491 (44.4%) distributed along the mutations. Of the positive results, the Frequency of the mutations was as follows, the M694V was the most common mutation 30%, followed by E 148Q 21.5%, V 726 A 20%, M6801 G/C 9%, M6941 8.3%, P369s 3.7%, A744S 3.1% and 4.2% among the 4 remaining mutations.
conclusionFrequency of common mutations in our study show similar results in comparisons with Mediterranean countries like Egypt, Turkey, and Syria with the most common mutation in our study being M694V followed by E148 Q.
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