ArticleIndian journal of microbiology2016
Searching Biomarkers in the Sequenced Genomes of Staphylococcus for their Rapid Identification.
Article in Indian journal of microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Bacterial Populations in Subgingival Plaque Under Healthy and Diseased Conditions: Genomic Insights into Oral Adaptation Strategies byIndian journal of microbiology · 2020Article
- Mapping Microbial Capacities for Bioremediation: Genes to Genomics.Indian journal of microbiology · 2020Review
- Aligning Microbial Biodiversity for Valorization of Biowastes: Conception to Perception.Indian journal of microbiology · 2019Review
- Contraceptive Sperm Agglutinating Proteins Identified inIndian journal of microbiology · 2019Article
- Integrated Artificial Intelligence Approaches for Disease Diagnostics.Indian journal of microbiology · 2018Article
- AnJournal, genetic engineering & biotechnology · 2017Article
- Gene Specific Impedimetric Bacterial DNA Sensor for Rheumatic Heart Disease.Indian journal of microbiology · 2017Article
- Comparative Genomics Reveals Biomarkers to Identify Lactobacillus Species.Indian journal of microbiology · 2016Article
- An In Silico Approach for Identification of the Pathogenic Species, Helicobacter pylori and Its Relatives.Indian journal of microbiology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial identification using rrs (16S rRNA) gene is widely reported. Bacteria possessing multiple copies of rrs lead to overestimation of its diversity. Staphylococcus genomes carries 5-6 copies of rrs showing high similarity in their nucleotide sequences, which lead to ambiguous results. The genomes of 31 strains of Staphylococcus representing 7 species were searched for the presence of common genes. In silico digestion of 34 common genes using 10 restriction endonucleases (REs) lead to select gene-RE combinations, which could be used as biomarkers. RE digestion of recA allowed unambiguous identification of 13 genomes representing all the 7 species. In addition, a few more genes (argH, argR, cysS, gyrB, purH, and pyrE) and RE combinations permitted further identification of 12 strains. By employing additional RE and genes unique to a particular strain, it was possible to identify the rest 6 Staphylococcus aureus strains. This approach has the potential to be utilized for rapid detection of Staphylococcus strains.
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