ArticleMagnetic resonance in medicine2017
Mapping immune cell infiltration using restricted diffusion MRI.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Parcellation-based tractographic modeling of the salience network through meta-analysis.Brain and behavior · 2022Pooled it
- Hubs of long-distance co-alteration characterize brain pathology.Human brain mapping · 2020Pooled it
- Spinal cord stimulation for upper limb motor function in people with chronic post-stroke hemiparesis: a feasibility trial.Nature medicine · 2026Trial
- Surgery versus Botulinum Toxin A for Treatment of Post-Stroke Upper-Limb Spasticity: White Matter Changes, Function, and Quality-of-Life-A Randomized Controlled Trial.Neural plasticity · 2026Trial
- Trial
- Post-stroke enriched auditory environment induces structural connectome plasticity: secondary analysis from a randomized controlled trial.Brain imaging and behavior · 2022Trial
- Trial
- Structural connectivity of auditory-linguistic brain networks predicts success in speech categorization and listening in noise.Neuroscience · 2026Article
- Article
- Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating From Axonal Polyneuropathies.Journal of magnetic resonance imaging : JMRI · 2026Article
- Causal evidence from invasive recordings reveals distributed acoustic feature encoding underlying categorical voice perception.NeuroImage · 2026Article
- Creativity: a (white) matter of connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cerebellar Tracts Microstructural Characteristics and Severity of Language Impairment in Post-stroke Patients with Aphasia: A DTI Study.Cerebellum (London, England) · 2026Article
- Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.Nature human behaviour · 2026Article
- Reduced integrity in the frontal aslant tract's premotor connections is associated with dysfluency severity in stuttering.PNAS nexus · 2026Article
- Disrupted integration-segregation balance in the intact hemisphere in chronic spatial neglect.Brain structure & function · 2026Article
- Pitch as a Shared Code for Music and Speech: Behavioral and Neural Evidence From Stroke Patients.Brain and behavior · 2026Article
- Primary Somatosensory to Motor Cortex Microstructural Connectivity Predicts the Mu-Rhythm Phase Effect on Corticospinal Excitability: An EEG-TMS Study.Human brain mapping · 2026Article
- Inside the frontal face network: multimodal evidence for distinct emotional and motor resonance circuits.Brain structure & function · 2026Article
- Microstructural changes in memory-related brain regions of stroke-free patients with middle cerebral artery occlusion as revealed by diffusion spectrum imaging.Brain imaging and behavior · 2026Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeDiffusion MRI provides a noninvasive way to assess tissue microstructure. Based on diffusion MRI, we propose a model-free method called restricted diffusion imaging (RDI) to quantify restricted diffusion and correlate it with cellularity. THEORY AND
methodsAn analytical relation between q-space signals and the density of restricted spins was derived to quantify restricted diffusion. A phantom study was conducted to investigate the performance of RDI, and RDI was applied to an animal study to assess immune cell infiltration in myocardial tissues with ischemia-reperfusion injury.
resultsOur phantom study showed a correlation coefficient of 0.998 between cell density and the restricted diffusion quantified by RDI. The animal study also showed that the high-value regions in RDI matched well with the macrophage infiltration areas in the H&E stained slides. In comparison with diffusion tensor imaging (DTI), RDI exhibited its outperformance to detect macrophage infiltration and delineate inflammatory myocardium.
conclusionRDI can be used to reveal cell density and detect immune cell infiltration. RDI exhibits better specificity than the diffusivity measurement derived from DTI. Magn Reson Med 77:603-612, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.