Evidence map›Paper›PMID 26843517›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2016

Cytoskeletal architecture and cell motility remain unperturbed in mouse embryonic fibroblasts from Plk3 knockout mice.

Daniel R Michel, Kyu-Shik Mun, Chia-Chi Ho, Peter J Stambrook

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel R MichelDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Kyu-Shik MunDepartment of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
Chia-Chi HoDepartment of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
Peter J StambrookDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA peter.stambrook@uc.edu.
University of Cincinnati · US

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
Environmental exposure: Susceptibility alleles in a DNA damage response pathwayR01ES016625 · NIEHS · UNIVERSITY OF CINCINNATI · PI STAMBROOK, PETER J. · 2009 to 2013
$2.5M
One Way Micropatterns for Self-Assembly and Sorting of CellsR01EB010043 · NIBIB · UNIVERSITY OF CINCINNATI · PI HO, CHIA-CHI · 2010 to 2013
$1.3M
Biomaterials Directed Cell Polarity and MigrationR01GM112017 · NIGMS · UNIVERSITY OF CINCINNATI · PI HO, CHIA-CHI · 2014 to 2016
$992k
NIBIB NIH HHS R01 EB010043NIBIB NIH HHS R01EB010043NIEHS NIH HHS R01 ES016625NIEHS NIH HHS R01ES016625NIEHS NIH HHS T32 ES007250NIEHS NIH HHS T32 ES07250NIGMS NIH HHS R01 GM112017NIGMS NIH HHS R01GM112017
6 · The paper itself

Abstract

Polo-like kinase 3 (Plk3) is best known for its involvement in cell cycle checkpoint regulation following exposure to cytotoxicants or induction of DNA damage. Yet, Plk3 has also been implicated in roles beyond those of cellular responses to DNA damage. Here, we have investigated the proposition, suggested by the Plk literature, that Plk3 regulates cytoskeletal architecture and cell functions mediated by the cytoskeleton. To this end, we have assayed mouse embryonic fibroblasts (MEFs) generated from both Plk3 knockout and wild-type mice. In particular, we asked whether Plk3 is involved in actin fiber and microtubule integrity, cell migration, cell attachment, and/or cell invasion. Our results demonstrate that functional Plk3 is not critical for the regulation of cytoskeletal integrity, cell morphology, cell adhesion, or motility in MEFs.

Indexed as

Cell MovementAnimalsCell AdhesionCytoskeletonFemaleFibroblastsMice, KnockoutProtein Serine-Threonine KinasesPlk3 protein, mouseProtein Serine-Threonine Kinasesand attachmentcell migrationcell motilitycytoskeletonplk3Polo-like kinase

Identifiers

PMID26843517
PMCPMC4950333
OpenAlexW2303012040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.