Evidence map›Paper›PMID 26843393›Full record

ArticleJournal of assisted reproduction and genetics2016

Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois.

Barbara Luke, Morton B Brown, Logan G Spector, Judy E Stern, Yolanda R Smith, Melanie Williams, Lori Koch, Maria J Schymura

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Barbara LukeDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, 965 Fee Road, East Fee Hall, Room 628, East Lansing, Michigan, 48824, USA. lukeb@msu.edu.ORCID http://orcid.org/0000-0002-0405-8133
Morton B BrownDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Judy E SternDepartment of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Yolanda R SmithDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
Melanie WilliamsTexas Cancer Registry, Cancer Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, USA.
Lori KochIllinois State Cancer Registry, Illinois Department of Public Health, Springfield, Illinois, USA.
Maria J SchymuraNew York State Cancer Registry, Bureau of Cancer Epidemiology, New York State Department of Health, Albany, New York, USA.
University of Michigan · USDartmouth College · USIllinois Department of Public Health · USMichigan State University · USNew York State Department of Health · USTexas Department of State Health Services · USUniversity of Minnesota · US

Funding

Assisted Reproductive Technology & Risk of Childhood CancerR01CA151973 · NCI · MICHIGAN STATE UNIVERSITY · PI LUKE, BARBARA JOAN, SPECTOR, LOGAN G. · 2011 to 2015
$3.0M
6 · The paper itself

Abstract

purposeThe purpose of the present study is to estimate the proportion of women with cancer who return to use the embryos that they have banked and to compare this proportion to that of women without cancer who bank embryos.

methodsThis is a cohort study of three groups of women from New York, Texas, and Illinois who used embryo banking in their first assisted reproductive technology (ART) treatment cycle: two groups with cancer (222 women without an infertility diagnosis and 48 women with an infertility diagnosis) and a control group without cancer (68 women with the infertility diagnosis of male factor only). Women were included only if their first ART cycle reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) occurred between 2004 and 2009. Cancer cases were identified from each State Cancer Registry from 5 years prior to initiation of ART treatment to 6 months post-initiation; mean follow-up after the first ART cycle was 2.0 years.

resultsWomen with cancer without an infertility diagnosis returned for a subsequent ART cycle at a lower rate (10.8 %) than those with an infertility diagnosis (31.3 %, p = 0.0010) or the control group (85.3 %, p < 0.0001). Among those who returned for a subsequent cycle, women with cancer waited a longer time to return (14.3 months without an infertility diagnosis and 8.3 months with an infertility diagnosis, p = 0.13) compared to the control group (2.8 months, p = 0.0007). The live birth rate among women who did not utilize embryo banking in their second cycle did not differ significantly across the three study groups, ranging from 25.0 and 42.9 % for women with cancer with and without an infertility diagnosis, respectively, to 36.2 % for women in the control group.

conclusionsWomen with cancer without an infertility diagnosis are either less likely to return for subsequent treatment or will wait a longer time to return than women with an infertility diagnosis or those that do not have cancer. A longer-term study is necessary to assess whether these women return to use their frozen embryos after cancer treatment or are able to spontaneously conceive and if those subsequent pregnancies are adversely affected by the cancer diagnosis or therapy.

Indexed as

AdultBirth RateCohort StudiesCryopreservationFemaleHumansIllinoisLive BirthNeoplasmsNew YorkPilot ProjectsReproductive Techniques, AssistedTexasAssisted reproductionCancer among womenCohort studyOncofertility

Identifiers

PMID26843393
PMCPMC4870436
OpenAlexW2290357379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.