ArticleJournal of assisted reproduction and genetics2016
Artificial shrinkage of blastocoel using a laser pulse prior to vitrification improves clinical outcome.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Vitrification with shortened equilibration across human embryonic developmental stages: a proof-of-concept study.Human reproduction open · 2026Article
- Impact of varicocelectomy prior ICSI on clinical and neonatal outcomes: A multilevel analysis.Arab journal of urology · 2026Article
- Advanced strategies for single embryo selection in assisted human reproduction: A review of clinical practice and research methods.Clinical and experimental reproductive medicine · 2025Article
- Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview.Journal of clinical medicine · 2024Review
- Embryo re-expansion does not affect clinical pregnancy rates in frozen embryo transfer cycles: a retrospective study.Journal of assisted reproduction and genetics · 2021Article
- Current and Future Perspectives for Improving Ovarian Tissue Cryopreservation and Transplantation Outcomes for Cancer Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Equilibrium vitrification of mouse embryos at various developmental stages using low concentrations of cryoprotectants.The Journal of reproduction and development · 2021Article
- Diagnostic efficiency of blastocyst culture medium in noninvasive preimplantation genetic testing.F&S reports · 2021Article
- Effect of equilibration time on clinical and neonatal outcomes in human blastocysts vitrification.Reproductive medicine and biology · 2020Article
- Minimally Invasive Cell-Free Human Embryo Aneuploidy Testing (miPGT-A) Utilizing Combined Spent Embryo Culture Medium and Blastocoel Fluid -Towards Development of a Clinical Assay.Scientific reports · 2020Article
- State of the Art in Fertility Preservation for Female Patients Prior to Oncologic Therapies.Medicina (Kaunas, Lithuania) · 2020Review
- Effect on clinical and neonatal outcomes of blastocelic microsuction prior to vitrification.Reproductive medicine and biology · 2019Article
- Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C.Scientific reports · 2019Article
- Article
- Effect of different artificial shrinkage methods, when applied before blastocyst vitrification, on perinatal outcomes.Reproductive biology and endocrinology : RB&E · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBlastocysts contain a large amount of fluid in the blastocoel, which may pose a risk for ice crystal formation during vitrification. This study aimed to evaluate the effectiveness of laser-induced artificial shrinkage of blastocoel before vitrification on clinical outcome.
methodsPatients were divided into two groups: a control group with untreated, expanded blastocysts (n = 115) and a study group with blastocoel artificially eliminated by a laser pulse prior to vitrification (n = 309). Blastocyst survival, clinical pregnancy, and implantation rates were compared. RESULT(S): The survival rate was significantly higher in the study group compared with the control group (97.3 and 74.9 %, respectively; p > 0.01). The clinical pregnancy and implantation rates of the study group were significantly higher (p < 0.01) than that of the control group (clinical pregnancy, 67.2 vs. 41.1 %; implantation, 39.1 vs. 24.5 %. CONCLUSION(S): This study demonstrated that the removal of blastocoel fluid before vitrification by laser pulse of in vitro-produced human blastocysts significantly improves blastocyst survival, clinical pregnancy, and implantation rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.