ReviewNature reviews. Cardiology2016
The rise, fall, and possible resurrection of renal denervation.
Review in Nature reviews. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry.European heart journal · 2017Trial
- Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan.Acta physiologica (Oxford, England) · 2026Article
- Renal Denervation Ameliorates Cardiomyocyte Apoptosis in Myocardial Ischemia-Reperfusion Injury Through Regulating Mitochondria-Endoplasmic Reticulum Contact.Anatolian journal of cardiology · 2024Article
- Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study.Scientific reports · 2023Article
- Article
- Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development.Frontiers in physiology · 2021Review
- Renal sympathetic denervation for resistant hypertension: where do we stand after more than a decade.Jornal brasileiro de nefrologia · 2020Review
- Renal Innervation in Resistant Hypertension: A Review of Pathophysiology and Renal Denervation as Potential Treatment.Current hypertension reviews · 2020Review
- Renewed hopes for renal denervation in hypertension.Nature reviews. Cardiology · 2018Article
- Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.Physiological reports · 2018Article
- Article
- Reply: Platelet noradrenaline overload - cause of increased noradrenaline spillover in hypertension?Nature reviews. Cardiology · 2016Article
- Reply: Platelet noradrenaline uptake is unrelated to renal denervation.Nature reviews. Cardiology · 2016Article
- Getting approval for new therapeutic medical devices versus drugs: are the differences justified?European respiratory review : an official journal of the European Respiratory Society · 2016Article
- [Invasive treatment of hypertension : Update 2016].Der Internist · 2016Review
- Renal denervation for resistant hypertension: the wrong target?Nature reviews. Cardiology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal denervation has a chequered history. Dramatic reductions in blood pressure after denervation of the renal arteries were observed in early trials, but later trials in which denervation was tested against a sham procedure produced neutral results. Although a sound pathophysiological basis exists for interruption of the renal sympathetic nervous system as a treatment for hypertension, trial data to date are insufficient to support renal denervation as an established clinical therapy. In this Perspectives article, we summarize the currently available trial data, device development, and trials in progress, and provide recommendations for future trial design.
Indexed as
Identifiers
26843285What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.