ArticleNeuroradiology2016
Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.Brain imaging and behavior · 2025Pooled it
- Effects of Motor Imagery Training Based on Near-Infrared Functional Brain Imaging on Upper Limb Function in Stroke Patients: A Randomized Controlled Trial.Brain topography · 2026Trial
- Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2025Trial
- Alterations in functional connectivity in patients with non-specific chronic low back pain after motor control exercise: a randomized trial.European journal of physical and rehabilitation medicine · 2024Trial
- Evidence of mirror therapy for recruitment of ipsilateral motor pathways in stroke recovery: A resting fMRI study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Trial
- Effects of bihemispheric transcranial direct current stimulation on motor recovery in subacute stroke patients: a double-blind, randomized sham-controlled trial.Journal of neuroengineering and rehabilitation · 2023Trial
- Motor network reorganization after motor imagery training in stroke patients with moderate to severe upper limb impairment.CNS neuroscience & therapeutics · 2023Trial
- Predicting upper limb motor recovery in subacute stroke patients via fNIRS-measured cerebral functional responses induced by robotic training.Journal of neuroengineering and rehabilitation · 2024Article
- Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults.Sports medicine - open · 2024Article
- Frequency specific alterations of the degree centrality in patients with acute basal ganglia ischemic stroke: a resting-state fMRI study.Brain imaging and behavior · 2024Article
- A Comprehensive Review on the Role of Resting-State Functional Magnetic Resonance Imaging in Predicting Post-Stroke Motor and Sensory Outcomes.Neurology international · 2024Review
- Motor imagery therapy improved upper limb motor function in stroke patients with hemiplegia by increasing functional connectivity of sensorimotor and cognitive networks.Frontiers in human neuroscience · 2024Article
- Relationship between resting-state functional connectivity and change in motor function after motor imagery intervention in patients with stroke: a scoping review.Journal of neuroengineering and rehabilitation · 2023Article
- Effect of immersive virtual mirror visual feedback on Mu suppression and coherence in motor and parietal cortex in stroke.Scientific reports · 2023Article
- Changes in Resting-State Neural Activity and Nerve Fibres in Ischaemic Stroke Patients with Hemiplegia.Brain topography · 2023Article
- Posterior parietal cortical areas and recovery after motor stroke: a scoping review.Brain communications · 2023Article
- Alterations of dynamic and static brain functional activities and integration in stroke patients.Frontiers in neuroscience · 2023Article
- Scalp acupuncture regulates functional connectivity of cerebral hemispheres in patients with hemiplegia after stroke.Frontiers in neurology · 2023Article
- Altered directional functional connectivity underlies post-stroke cognitive recovery.Brain communications · 2023Article
- Amplitude of low-frequency fluctuations in multiple-frequency bands in patients with intracranial tuberculosis: a prospective cross-sectional study.Quantitative imaging in medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionResting-state functional magnetic resonance imaging (fMRI) has been used to examine the brain mechanisms of stroke patients with hemiplegia, but the relationship between functional connectivity (FC) and treatment-induced motor function recovery has not yet been fully investigated. This study aimed to identify the brain FC changes in stroke patients and study the relationship between FC and motor function assessment using the resting-state fMRI.
methodsSeventeen stroke patients with hemiplegia and fifteen healthy control subjects (HCSs) were recruited in this study. We compared the FC between the ipsilesional primary motor cortex (M1) and the whole brain of the patients with the FC of the HCSs and studied the FC changes in the patients before and after conventional rehabilitation and motor imagery therapy. Additionally, correlations between the FC change and motor function of the patients were studied.
resultsCompared to the HCSs, the FC in the patient group was significantly increased between the ipsilesional M1 and the ipsilesional inferior parietal cortex, frontal gyrus, supplementary motor area (SMA), and contralesional angular and decreased between the ipsilesional M1 and bilateral M1. After the treatment, the FC between the ipsilesional M1 and contralesional M1 increased while the FC between the ipsilesional M1 and ipsilesional SMA and paracentral lobule decreased. A statistically significant correlation was found between the FC change in the bilateral M1 and the Fugl-Meyer assessment (FMA) score change.
conclusionOur results revealed an abnormal motor network after stroke and suggested that the FC could serve as a biomarker of motor function recovery in stroke patients with hemiplegia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.