ArticleThe American journal of clinical nutrition2016
Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Current Evidence on Associations of Nutritional Factors with Ovarian Reserve and Timing of Menopause: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study.Paediatric and perinatal epidemiology · 2021Trial
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- Hormone Fluctuations, Dietary Intake, and Daily Activity in Premenopausal Women: An 8-Week Observational Study.Translational journal of the American College of Sports Medicine · 2026Article
- Neighborhood disadvantage and fecundability in a cohort of US Black women.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Urinary phthalates, serum omega-3 fatty acids and ovarian reserve among women seeking fertility treatment.International journal of hygiene and environmental health · 2025Article
- The association of dietary fat and fatty acid intake with ovarian cancer survival: findings from the OOPS, a prospective cohort study.Nutrition journal · 2025Article
- A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?Journal of translational medicine · 2025Review
- Diet and female fertility: a population-based study re-evaluating the need for prescriptive dietary patterns.Frontiers in nutrition · 2025Article
- Nutritional Interventions for Enhancing Female Fertility: A Comprehensive Review of Micronutrients and Their Impact.Nursing research and practice · 2025Review
- Article
- Association between serum unsaturated fatty acids levels and infertility among American women from the National Health and Nutrition Examination Survey 2013-2014.Lipids in health and disease · 2024Article
- Correlation between cardiometabolic index and female infertility: a cross-sectional analysis.Reproductive biology and endocrinology : RB&E · 2024Article
- Article
- Dietary and Lifestyle Management of Functional Hypothalamic Amenorrhea: A Comprehensive Review.Nutrients · 2024Review
- Healthy eating index and risk of diminished ovarian reserve: a case-control study.Scientific reports · 2024Article
- Review
- The impact of ketogenic diet on some metabolic and non-metabolic diseases: Evidence from human and animal model experiments.Food science & nutrition · 2024Review
- Rapid Analysis of Estrogens in Meat Samples by High Performance Liquid Chromatography with Fluorescence Detection.Journal of fluorescence · 2024Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundEmerging evidence suggests potential links between some dietary fatty acids and improved fertility, because specific fatty acids may affect prostaglandin synthesis and steroidogenesis.
objectiveThe objective of this exploratory study was to evaluate associations between total and specific types of dietary fat intake and 1) hormone concentrations and 2) the risk of sporadic anovulation in a cohort of 259 regularly menstruating women in the BioCycle Study.
designEndogenous reproductive hormones were measured up to 8 times/cycle for up to 2 cycles, with visits scheduled with the use of fertility monitors. Dietary intake was assessed with up to four 24-h recalls/cycle. Linear mixed models and generalized linear models were used to evaluate the associations between dietary fatty acids and both reproductive hormone concentrations and ovulatory status. All models were adjusted for total energy intake, age, body mass index, and race.
resultsRelative to the lowest levels of percentage of energy from total fat, the highest tertile was associated with increased total and free testosterone concentrations (total: percentage change of 4.0%; 95% CI: 0.7%, 7.3%; free: percentage change of 4.1%; 95% CI: 0.5%, 7.7%). In particular, the percentage of energy from polyunsaturated fatty acids (PUFAs) in the highest tertile was associated with increases in total and free testosterone (total: percentage change of 3.7%; 95% CI: 0.6%, 6.8%; free: percentage change of 4.0%; 95% CI: 0.5%, 7.5%). The PUFA docosapentaenoic acid (22:5n-3) was not significantly associated with testosterone concentrations (P-trend = 0.86 in energy substitution models) but was associated with increased progesterone and a reduced risk of anovulation (highest tertile compared with the lowest tertile: RR: 0.42; 95% CI: 0.18, 0.95). Fat intakes were not associated with other reproductive hormone concentrations.
conclusionsThese results indicate that total fat intake, and PUFA intake in particular, is associated with very small increases in testosterone concentrations in healthy women and that increased docosapentaenoic acid was associated with a lower risk of anovulation.
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Registered trials
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