ArticleScientific reports2016
Human oral isolate Lactobacillus fermentum AGR1487 induces a pro-inflammatory response in germ-free rat colons.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- An Overview of the Use and Applications ofMicroorganisms · 2023Review
- Exploring the Benefits of Probiotics in Gut Inflammation and Diarrhea-From an Antioxidant Perspective.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Complete Annotated Genome Sequence of Limosilactobacillus fermentum AGR1487.Microbiology resource announcements · 2021Article
- Complete Genome Sequence of Lactobacillus fermentum Strain AGR1485, a Human Oral Isolate.Microbiology resource announcements · 2020Article
- Compositional changes to the ileal microbiome precede the onset of spontaneous ileitis in SHIP deficient mice.Gut microbes · 2019Article
- Isolation and characterization of five novel probiotic strains from Korean infant and children faeces.PloS one · 2019Article
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Authors and funding
9 authors.
Funding
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Abstract
Lactobacilli are thought to be beneficial for human health, with lactobacilli-associated infections being confined to immune-compromised individuals. However, Lactobacillus fermentum AGR1487 negatively affects barrier integrity in vitro so we hypothesized that it caused a pro-inflammatory response in the host. We compared germ-free rats inoculated with AGR1487 to those inoculated with another L. fermentum strain, AGR1485, which does not affect in vitro barrier integrity. We showed that rats inoculated with AGR1487 had more inflammatory cells in their colon, higher levels of inflammatory biomarkers, and increased colonic gene expression of pro-inflammatory pathways. In addition, our in vitro studies showed that AGR1487 had a greater capacity to activate TLR signaling and induce pro-inflammatory cytokines in immune cells. This study indicates the potential of strains of the same species to differentially elicit inflammatory responses in the host and highlights the importance of strain characterization in probiotic approaches to treat inflammatory disorders.
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