Evidence map›Paper›PMID 26843111›Full record

ArticleMolecular neurobiology2017

Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation.

Romana Bohuslavova, Nicole Dodd, Iva Macova, Tetyana Chumak, Martin Horak, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Overexpression ofInternational journal of molecular sciences · 2021
    Article
  3. Molecular Aspects of the Development and Function of Auditory Neurons.International journal of molecular sciences · 2020
    Review
  4. Article
  5. Neurod1 Is Essential for the Primary Tonotopic Organization and Related Auditory Information Processing in the Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  6. Mice LackingFrontiers in behavioral neuroscience · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Romana BohuslavovaInstitute of Biotechnology CAS, Prumyslova 595, Vestec, Prague-West District, 25242, Czech Republic.
Nicole DoddInstitute of Biotechnology CAS, Prumyslova 595, Vestec, Prague-West District, 25242, Czech Republic.
Iva MacovaInstitute of Biotechnology CAS, Prumyslova 595, Vestec, Prague-West District, 25242, Czech Republic.
Tetyana ChumakInstitute of Experimental Medicine CAS, Prague, Czech Republic.
Martin HorakInstitute of Physiology CAS, Prague, Czech Republic.
Josef SykaInstitute of Experimental Medicine CAS, Prague, Czech Republic.
Bernd FritzschDepartment of Biology, University of Iowa, Iowa City, IA, USA.
Gabriela PavlinkovaInstitute of Biotechnology CAS, Prumyslova 595, Vestec, Prague-West District, 25242, Czech Republic. gpavlinkova@ibt.cas.cz.
Czech Academy of Sciences, Institute of Biotechnology · CZCzech Academy of Sciences, Institute of Experimental Medicine · CZCzech Academy of Sciences, Institute of Physiology · CZUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The programming of cell fate by transcription factors requires precise regulation of their time and level of expression. The LIM-homeodomain transcription factor Islet1 (Isl1) is involved in cell-fate specification of motor neurons, and it may play a similar role in the inner ear. In order to study its role in the regulation of vestibulo-motor development, we investigated a transgenic mouse expressing Isl1 under the Pax2 promoter control (Tg

Indexed as

AnimalsCerebellumFemaleHyperkinesisLIM-Homeodomain ProteinsMaleMiceMice, TransgenicPAX2 Transcription FactorTranscription FactorsVestibule, Labyrinthinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsPax2 protein, mousePAX2 Transcription FactorTranscription FactorsAge-related deterioration of Purkinje cellsAttention deficit hyperactivity disorderCalcium homeostasisCerebellumFoliation defectsGABA signalingHyperactivityIslet1 transcription factorPurkinje cellsTransgenic mouseVestibular system

Identifiers

PMID26843111
PMCPMC5310572
OpenAlexW2272709557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.