SynthesisItalian journal of pediatrics2016
Association between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-analysis of epidemiological observational studies.
Synthesis in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of Korean medical science · 2021Pooled it
- Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants.Frontiers in cardiovascular medicine · 2021Pooled it
- [Association between maternal alcohol consumption and risk of congenital heart disease in offspring: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Pooled it
- Cardiovascular and Cardiometabolic Outcomes in Adults with Fetal Alcohol Spectrum Disorders: A Retrospective Cohort Study.medRxiv : the preprint server for health sciences · 2026Article
- Risk assessment of congenital heart defects based on maternal factors in early pregnancy-a systematic review and meta-analysis.Frontiers of medicine · 2025Review
- Prevalence of congenital heart defects among children with and without diagnosed fetal alcohol spectrum disorders, 2016-2022.Drug and alcohol dependence · 2025Article
- The Critical Role of Pulse Oximetry Screening for Congenital Heart Disease and Patent Ductus Arteriosus in Newborns.Cureus · 2024Article
- Cardiac Magnetic Resonance Imaging in Individuals With Prenatal Alcohol Exposure.CJC pediatric and congenital heart disease · 2023Article
- The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study.BMC medicine · 2023Article
- Maternal sociodemographic characteristics, early pregnancy behaviours, and livebirth outcomes as congenital heart defects risk factors - Northern Ireland 2010-2014.BMC pregnancy and childbirth · 2021Article
- Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study.Pediatric research · 2021Article
- Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study.Journal of the American Heart Association · 2021Article
- The effect of maternal pre-/early-pregnancy BMI and pregnancy smoking and alcohol on congenital heart diseases: a parental negative control study.medRxiv : the preprint server for health sciences · 2020Article
- The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy.Nutrients · 2020Review
- G9α-dependent histone H3K9me3 hypomethylation promotes overexpression of cardiomyogenesis-related genes in foetal mice.Journal of cellular and molecular medicine · 2020Article
- Associations of trace elements in blood with the risk of isolated ventricular septum defects and abnormal cardiac structure in children.Environmental science and pollution research international · 2019Article
- PDGFRA gene, maternal binge drinking and obstructive heart defects.Scientific reports · 2018Article
- Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.Italian journal of pediatrics · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the association between maternal alcohol consumption and/or binge drinking and congenital heart defects (CHDs), we conducted a meta-analysis for more sufficient evidence on this issue.
methodsWe searched Medline, EMBASE, and the Cochrane Library from their inceptions to December 2014 for case-control and cohort studies that assessed the association between maternal alcohol consumption and CHD risk. Study-specific relative risk estimates were calculated using random-effect or fixed-effect models.
resultsA total of 19 case-control studies and 4 cohort studies were included in the meta-analysis. We observed a null association between maternal alcohol consumption during pregnancy and the risk of CHDs. Even in the analysis of different trimesters of pregnancy, we found little association between the two.
conclusionsThis meta-analysis suggests that maternal alcohol consumption is modestly not associated with the risk of CHDs. However, further investigation is needed to confirm this conclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.