ArticleCNS neuroscience & therapeutics2016
The Neural Basis of Postural Instability Gait Disorder Subtype of Parkinson's Disease: A PET and fMRI Study.
Article in CNS neuroscience & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Meta analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS Reveals emergence of adaptive brain glucometabolic responses and associated neurological functional profiles.medRxiv : the preprint server for health sciences · 2026Article
- Energetic implications of fMRI-based nodal complex network metrics: a complex picture unfolds across diverse brain states.bioRxiv : the preprint server for biology · 2026Article
- Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Metabolomics in Parkinson's Disease and Correlation with Disease State.Metabolites · 2025Review
- Multi-modality radiomics of conventional T1 weighted and diffusion tensor imaging for differentiating Parkinson's disease motor subtypes in early-stages.Scientific reports · 2024Article
- Resting-state functional connectivity of the occipital cortex in different subtypes of Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Neuroimaging correlates of postural instability in Parkinson's disease.Journal of neurology · 2024Article
- Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- The effects of AQP4 rs162009 on resting-state brain activity in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Cerebellar alterations in Parkinson's disease with postural instability and gait disorders.Journal of neurology · 2023Article
- Structural and functional differences of the thalamus between drug-naïve Parkinson's disease motor subtypes.Frontiers in neurology · 2023Article
- Serial deep gray nuclear DTI changes in Parkinson's disease over twelve years.Frontiers in aging neuroscience · 2023Article
- Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson's Disease.Journal of personalized medicine · 2022Article
- On the Effects of Transcranial Direct Current Stimulation on Cerebral Glucose Uptake During Walking: A Report of Three Patients With Multiple Sclerosis.Frontiers in human neuroscience · 2022Article
- Tractography patterns of pedunculopontine nucleus deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review.Movement disorders clinical practice · 2021Review
- The Role of Electrochemical Skin Conductance as a Screening Test of Cardiovascular Autonomic Neuropathy in Patients with Parkinson's Disease.International journal of environmental research and public health · 2020Article
- Brain metabolic alterations herald falls in patients with Parkinson's disease.Annals of clinical and translational neurology · 2020Article
- Clinical implications of early caudate dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2019Article
- Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study.Journal of neurology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study is to further uncover the neural basis of postural instability gait disorder (PIGD) subtype of Parkinson's disease.
methodsWith F-18 fluorodeoxyglucose PET (FDG-PET), brain glucose metabolism of patients with PIGD (n = 15) was compared with healthy controls (n = 17) and tremor-dominant (TD) patients (n = 15), and the correlation between metabolism and PIGD symptoms was also assessed. Within PIGD symptom-correlated hypometabolic areas, the relationship of functional connectivity (FC) with motor and cognitive symptoms was examined by using functional MRI.
resultsCompared with controls, patients with PIGD displayed a distributed pattern of brain hypometabolism including striatal, frontal, and parietal areas. Relative to the pattern of TD patients, the pattern of patients with PIGD had additional metabolic decreases in caudate and inferior parietal lobule (IPL, Brodmann area [BA] 40). In PIGD group, the metabolic reductions in IPL (BA 40), middle frontal gyrus (MFG, BA 9) and fusiform gyrus (FG, BA 20) were associated with severe PIGD symptoms. Regions showing such correlation were chosen for further seed-based FC analysis. Decreased FC within the prefrontal-parietal network (between the MFG and IPL) was associated with severe PIGD symptoms.
conclusionThe involvement of the caudate, FG, and prefrontal-parietal network may be associated with the prominent gait impairments of PIGD subtype. Our findings expand the pathophysiological knowledge of PIGD subtype and provide valuable information for potential neuromodulation therapies alleviating gait disorders.
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