ArticleScientific reports2016
Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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Who cites it
66 citing papers in PubMed, 126 citations in OpenAlex.
- Hearing Loss, Cognitive Decline, and Dementia: Clinical Intersections.Audiology research · 2026Review
- Structural and Functional Brain Alterations Induced by Noise Exposure: A Comprehensive Review.NeuroSci · 2026Review
- Survey of Hippocampal Responses to Sound in Naive Mice Reveals Widespread Activation by Broadband Noise Onsets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- DNAH11 impairs memory via disrupted synaptic plasticity in noise-induced hidden hearing loss mice.Cell biology and toxicology · 2025Article
- Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.Scientific reports · 2025Article
- Is Work-Related Hearing Loss Associated With Dementia? Evidence From a High-Risk Population.American journal of industrial medicine · 2025Article
- Cognitive and Behavioural Associations of Visual and Hearing Impairments Across the Lifespan in People With Down Syndrome, a Scoping Review.Journal of intellectual disability research : JIDR · 2025Article
- Slight and hidden hearing loss differentially affect short- and long-term memory in young rats.Behavioural pharmacology · 2025Article
- Neural stem cell heterogeneity in adult hippocampus.Cell regeneration (London, England) · 2025Review
- The Influence of Noise Exposure on Cognitive Function in Children and Adolescents: A Meta-Analysis.NeuroSci · 2025Review
- Blood Neurofilament Light Chain and Phospho-Tau 181 in Subjects with Mild Cognitive Impairment Due to Age-Related Hearing Loss.Journal of clinical medicine · 2025Article
- Beyond the auditory system: cognitive implications of age-related hearing loss.Frontiers in aging neuroscience · 2025Review
- Conductive hearing loss does not affect spatial learning and memory in middle-aged guinea pigs.Scientific reports · 2024Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- The Impact of Persistent Noise Exposure under Inflammatory Conditions.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice.Brain sciences · 2023Article
- Association between Simultaneous Occurrence of Occupational Noise-Induced Hearing Loss and Noise-Induced Vestibular Dysfunction: A Systematic Review.Iranian journal of public health · 2023Review
- Auditory or Audiovisual Stimulation Ameliorates Cognitive Impairment and Neuropathology in ApoE4 Knock-In Mice.International journal of molecular sciences · 2023Article
- Hippocampal atrophy is associated with hearing loss in cognitively normal adults.Frontiers in neuroscience · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of the most common causes for acquired sensorineural hearing loss is exposure to excessive noise, which has been found to impair learning ability and cognitive performance in human subjects and animal models. Noise exposure has also been found to depress neurogenesis in the hippocampus. However, the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. In the present study, young adult CBA/CAJ mice (between 1.5 and 2 months of age) were briefly exposed a high sound level to produce moderate-to-severe hearing loss. In both the blood and hippocampus, only transient oxidative stress was observed after noise exposure. However, a deficit in spatial learning/memory was revealed 3 months after noise exposure. Moreover, the deficit was correlated with the degree of hearing loss and was associated with a decrease in neurogenesis in the hippocampus. We believe that the observed effects were likely due to hearing loss rather than the initial oxidant stress, which only lasted for a short period of time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.