Observational studyThe AAPS journal2016
Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women.
Observational study in The AAPS journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Article
- Iron Deficiency in Vegetarian Athletes: A Narrative Review.Current nutrition reports · 2026Review
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
- Cyclical fluctuations of iron biomarkers in women: Diagnostic implications for iron deficiency.Practical laboratory medicine · 2025Article
- Menstrual blood loss as an initial trigger for adaptation of iron metabolism in eumenorrheic female athletes-An exploratory study.Physiological reports · 2025Article
- Fluctuations and interrelationship of oxidative stress and hepcidin during the menstrual cycle.Frontiers in endocrinology · 2025Article
- Micronutrient bioavailability: concepts, influencing factors, and strategies for improvement.Frontiers in nutrition · 2025Review
- The effect of iron supplementation on menstrual bleeding volume and hemoglobin level during menstrual bleeding : A randomized clinical trial.Journal of education and health promotion · 2024Article
- Low haemoglobin in arduous seasons is associated with reduced chance of ovulation among women living in the BolivianEvolution, medicine, and public health · 2024Article
- International society of sports nutrition position stand: nutritional concerns of the female athlete.Journal of the International Society of Sports Nutrition · 2023Review
- Changes of Hepcidin, Ferritin and Iron Levels in Cycling Purebred Spanish Mares.Animals : an open access journal from MDPI · 2023Article
- Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females.Physiological reports · 2022Article
- A contemporary understanding of iron metabolism in active premenopausal females.Frontiers in sports and active living · 2022Review
- Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age.Nutrients · 2021Article
- Transcriptional Landscape ofMicroorganisms · 2020Article
- Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication.Molecular and cellular biochemistry · 2020Article
- Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age.Journal of Taibah University Medical Sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies. We used the data collected in the HEPMEN (named after HEPcidin during MENses) study to investigate the joint dynamics of serum hepcidin and iron during the menstrual cycle in healthy women. Ninety menstruating women were recruited after a screening visit. Six fasting blood samples for determination of iron-status variables were taken in the morning throughout the cycle, starting on the second day of the period. Non-linear mixed effect models were used to describe the evolution of iron and hepcidin. Demographic and medical covariates were tested for their effect on model parameters. Parameter estimation was performed using the SAEM algorithm implemented in the Monolix software. A general pattern was observed for both hepcidin and iron, consisting of an initial decrease during menstruation, followed by a rebound and stabilising during the second half of the cycle. We developed a joint model including a menstruation-induced decrease of both molecules at the beginning of the menses and a rebound effect after menses. Iron stimulated the release of hepcidin. Several covariates, including contraception, amount of blood loss and ferritin, were found to influence the parameters. The joint model of iron and hepcidin was able to describe the fluctuations induced by blood loss from menstruation in healthy non-menopausal women and the subsequent regulation. The HEPMEN study showed fluctuations of iron-status variables during the menstrual cycle, which should be considered when using hepcidin measurements for diagnostic purposes in women of child-bearing potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.