Evidence map›Paper›PMID 26842624›Full record

ReviewJournal of nephrology2016

IgM nephropathy: is it closer to minimal change disease or to focal segmental glomerulosclerosis?

R Brugnano, R Del Sordo, C Covarelli, E Gnappi, S Pasquali

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Observational
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  13. Clinical significance of IgM deposition in pediatric minimal change disease.International journal of pediatrics & adolescent medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R BrugnanoDepartment of Nephrology and Dialysis, S. Maria della Misericordia Hospital, Piazza Menghini, 1, San Sisto, 06156, Perugia, Italy. rbrugnano@libero.it.
R Del SordoDepartment of Experimental Medicine-Section of Pathological Anatomy and Histology, Medical School, University of Perugia, Perugia, Italy.
C CovarelliDepartment of Experimental Medicine-Section of Pathological Anatomy and Histology, Medical School, University of Perugia, Perugia, Italy.
E GnappiU.O.C Nephrology and Dialysis, S. Maria Nuova Hospital, Reggio Emilia, Italy.
S PasqualiU.O.C Nephrology and Dialysis, S. Maria Nuova Hospital, Reggio Emilia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin (Ig)M nephropathy (IgMN), known since 1978, is a very controversial clinicopathological entity characterized by IgM diffuse deposits in the mesangium at immunofluorescence whereas light microscop identifies minimal glomerular lesion, hypercellularity and expansion of the mesangium or sclerotic focal, segmental lesion. Clinically, it is a nephrotic syndrome, especially in pediatric patients, or asymptomatic proteinuria and/or isolated hematuria. These characteristics narrowly define IgMN between minimal change disease and focal segmental glomerulosclerosis, so it is not often recognized as a separate pathology. Homogeneous epidemiologic, pathogenetic, clinical or histological data are not available. Recent research on the pathogenetic role of mesangial IgM has, however, renewed interest in IgMN and naturally the controversies.

Indexed as

Immunoglobulin MFluorescent Antibody TechniqueGlomerulosclerosis, Focal SegmentalHumansKidney GlomerulusMicroscopy, ElectronNephrosis, LipoidNephrotic SyndromeImmunoglobulin MControversyFocal segmental glomerulosclerosisIgM nephropathyMinimal change diseaseNephrotic syndrome

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.