ArticlePlant biotechnology journal2016
Metabolic engineering of terpene biosynthesis in plants using a trichome-specific transcription factor MsYABBY5 from spearmint (Mentha spicata).
Article in Plant biotechnology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 125 citations in OpenAlex.
- The Phylogeny of Brassicaceae YABBYs and theInternational journal of molecular sciences · 2026Article
- A Novel CsYABBY3-CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- mRNA sequencing revealed transcriptional variability of terpene and eugenol synthase genes among distinct oil yielding accessions of Ocimum sanctum L.Scientific reports · 2026Article
- Crop biofortification for global food security: advances in genetic engineering and biotechnological approaches.Plant molecular biology · 2026Review
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- Glycyrrhiza, a commonly used medicinal herb: Review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology.Journal of advanced research · 2025Review
- Multidimensional regulation of transcription factors: decoding the comprehensive signals of plant secondary metabolism.Frontiers in plant science · 2025Review
- Transcriptomics Identifies Differentially Expressed Genes Inducing Tuber Formation in Early- and Late-Maturing Potatoes.Plants (Basel, Switzerland) · 2024Article
- Characterization of YABBY transcription factors in Osmanthus fragrans and functional analysis of OfYABBY12 in floral scent formation and leaf morphology.BMC plant biology · 2024Article
- Article
- Identification and expression analysis ofPlant signaling & behavior · 2023Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
- A Comprehensive Review of the Key Characteristics of the GenusIranian journal of biotechnology · 2023Review
- Multiomics comparison among populations of three plant sources of Amomi Fructus.Horticulture research · 2023Article
- Advances in the Biosynthesis of Terpenoids and Their Ecological Functions in Plant Resistance.International journal of molecular sciences · 2023Review
- Article
- Characterization of YABBY genes in Dendrobium officinale reveals their potential roles in flower development.Protoplasma · 2023Article
- Article
- Transcriptome sequencing and gas chromatography-mass spectrometry analyses provide insights into β-caryophyllene biosynthesis inFood chemistry. Molecular sciences · 2022Article
- Transcriptional Reactivation of Lignin Biosynthesis for the Heterologous Production of Etoposide Aglycone inACS synthetic biology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many aromatic plants including spearmint (Mentha spicata), the sites of secondary metabolite production are tiny specialized structures called peltate glandular trichomes (PGT). Having high commercial values, these secondary metabolites are exploited largely as flavours, fragrances and pharmaceuticals. But, knowledge about transcription factors (TFs) that regulate secondary metabolism in PGT remains elusive. Understanding the role of TFs in secondary metabolism pathway will aid in metabolic engineering for increased yield of secondary metabolites and also the development of new production techniques for valuable metabolites. Here, we isolated and functionally characterized a novel MsYABBY5 gene that is preferentially expressed in PGT of spearmint. We generated transgenic plants in which MsYABBY5 was either overexpressed or silenced using RNA interference (RNAi). Analysis of the transgenic lines showed that the reduced expression of MsYABBY5 led to increased levels of terpenes and that overexpression decreased terpene levels. Additionally, ectopic expression of MsYABBY5 in Ocimum basilicum and Nicotiana sylvestris decreased secondary metabolite production in them, suggesting that the encoded transcription factor is probably a repressor of secondary metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.