Evidence map›Paper›PMID 26842557›Full record

ArticleHuman cell2016

ALDH2 polymorphism for the risk of cervical carcinogenesis.

Osamu Nunobiki, Daisuke Sano, Kyoko Akashi, Taro Higashida, Toshitada Ogasawara, Hikari Akise, Shinji Izuma, Kiyo Torii, Yoshiaki Okamoto, Ichiro Tanaka and 1 more

Abstract read
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In one paragraph

Article in Human cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Osamu NunobikiDepartment of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan. o-nunobiki@kobe-tokiwa.ac.jp.
Daisuke SanoDepartment of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan.
Kyoko AkashiDepartment of Obstetrics and Gynecology, Kyoto Prefectural University, Kyoto, Japan.
Taro HigashidaDepartment of Obstetrics and Gynecology, Akou City Hospital, Akou, Hyogo, Japan.
Toshitada OgasawaraDepartment of Obstetrics and Gynecology, Okubo Hospital, Okubo, Hyogo, Japan.
Hikari AkiseCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Shinji IzumaCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Kiyo ToriiCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Yoshiaki OkamotoCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Ichiro TanakaCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Masatsugu UedaCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Osaka Medical Center for Cancer and Cardiovascular Diseases · JPKobe Tokiwa University · JPKyoto Prefectural University · JPOgikubo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the clinical significance of ALDH2 genetic polymorphisms in cervical carcinogenesis. ALDH2 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 195 cervical smear in exfoliated cervical cell samples using Real-Time polymerase chain reaction (PCR) System. The frequency for the AG+AA genotype was seven in the normal group (70.0 %), 16 in the LSIL group (57.1 %), and 27 in the HSIL group (90.0 %). A significant difference was found between the LSIL and HSIL groups (P = 0.0064). Patients with HSIL lesions frequently had high-risk HPV infections and concurrently belonged to the AG+AA group. ALDH2 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population.

Indexed as

Genetic Association StudiesAldehyde Dehydrogenase, MitochondrialFemaleGenetic Predisposition to DiseaseHumansPapillomaviridaePolymorphism, GeneticRiskRisk FactorsUterine Cervical NeoplasmsAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanALDH2Cervical carcinogenesisPolymorphismSIL

Identifiers

PMID26842557
OpenAlexW2253124797

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.