Evidence map›Paper›PMID 26842478›Full record

ReviewJournal of virology2016

The Barrier to Autointegration Factor: Interlocking Antiviral Defense with Genome Maintenance.

Matthew S Wiebe, Augusta Jamin

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
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  16. RareFrontiers in cell and developmental biology · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Matthew S WiebeSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska, USA mwiebe@unl.edu.
Augusta JaminDepartment of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Dana-Farber Cancer Institute · USUniversity of Nebraska–Lincoln · US

Funding

Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
Mechanism of the Antiviral Activity of BAF Against Poxvirus and HSV-1 InfectionR01AI114653 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI WIEBE, MATTHEW S · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI114653NIAID NIH HHS R01AI114653NIGMS NIH HHS P30 GM103509NIGMS NIH HHS P30GM103509
6 · The paper itself

Abstract

Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.

Indexed as

Genome, HumanVirus IntegrationDNA-Binding ProteinsDNA, ViralHumansNuclear ProteinsBANF1 protein, humanDNA-Binding ProteinsDNA, ViralNuclear Proteins

Identifiers

PMID26842478
PMCPMC4810535
OpenAlexW2254627828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.