ArticleJournal of muscle research and cell motility2016
Improving human skeletal muscle myosin heavy chain fiber typing efficiency.
Article in Journal of muscle research and cell motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Optimizing the methodology for precise estimation of skeletal muscle fiber type proportions in humans.Scientific reports · 2025Article
- Muscle fiber phenotype: a culprit of abnormal metabolism and function in skeletal muscle of humans with obesity.American journal of physiology. Endocrinology and metabolism · 2023Review
- Exercise and Experiments of Nature.Comprehensive Physiology · 2023Article
- THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres.The Journal of physiology · 2022Article
- Skeletal Muscle Adaptations and Performance Outcomes Following a Step and Exponential Taper in Strength Athletes.Frontiers in physiology · 2021Article
- Fiber typing human skeletal muscle with fluorescent immunohistochemistry.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Article
- Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits.European journal of applied physiology · 2018Article
- Mechanisms of sarcopenia: motor unit remodelling and muscle fibre type shifts with ageing.The Journal of physiology · 2018Article
- Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single muscle fiber sodium dodecyl sulfate polyacrylamide gel-electrophoresis (SDS-PAGE) is a sensitive technique for determining skeletal muscle myosin heavy chain (MHC) composition of human biopsy samples. However, the number of fibers suitable to represent fiber type distribution via this method is undefined. Muscle biopsies were obtained from the vastus lateralis (VL) of nine resistance-trained males (25 ± 1 year, height = 179 ± 5 cm, mass = 82 ± 8 kg). Single fiber MHC composition was determined via SDS-PAGE. VL fiber type distribution [percent MHC I, I/IIa, IIa, IIa/IIx, and total "hybrids" (i.e. I/IIa + IIa/IIx)] was evaluated according to number of fibers analyzed per person (25 vs. 125). VL fiber type distribution did not differ according to number of fibers analyzed (P > 0.05). VL biopsy fiber type distribution of nine subjects is represented by analyzing 25 fibers per person. These data may help minimize cost, personnel-time, and materials associated with this technique, thereby improving fiber typing efficiency in humans.
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