ArticleNature communications2016
Microbial metabolomics in open microscale platforms.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Mixed Strain Fermentation and Metabonomics for Solving Issues of Bioproduction.Advances in biochemical engineering/biotechnology · 2025Review
- Similarity in the microbial community structure of tobacco from geographically similar regions.Scientific reports · 2024Article
- Exploring interspecific interaction variability in microbiota: A review.Engineering microbiology · 2024Review
- Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mannitol mediates the mummification behavior ofFrontiers in microbiology · 2024Article
- Sample Preparation in Microbial Metabolomics: Advances and Challenges.Advances in experimental medicine and biology · 2023Article
- Discovering New Natural Products Using Metabolomics-Based Approaches.Advances in experimental medicine and biology · 2023Article
- Metabolites and Their Bioactivities from the GenusMicroorganisms · 2022Review
- Electrotransfer of Immunoprobes through Thin-Layer Polyacrylamide Gels.Analytical chemistry · 2022Article
- Synergistic effect of co-culture rhizosphereFrontiers in microbiology · 2022Article
- SubTap, a Versatile 3D Printed Platform for Eavesdropping on Extracellular Interactions.mSystems · 2021Article
- Micro-Technologies for Assessing Microbial Dynamics in Controlled Environments.Frontiers in microbiology · 2021Review
- Catch the wave: Metabolomic analyses in human pathogenic fungi.PLoS pathogens · 2020Article
- Active particles as mobile microelectrodes for selective bacteria electroporation and transport.Science advances · 2020Article
- Droplet Incubation and Splitting in Open Microfluidic Channels.Analytical methods : advancing methods and applications · 2019Article
- Open Microfluidic Capillary Systems.Analytical chemistry · 2019Article
- Microbial biospherics: The experimental study of ecosystem function and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Stable biphasic interfaces for open microfluidic platforms.Biomedical microdevices · 2019Article
- Effects of Moxibustion and Moxa Smoke on Behavior Changes and Energy Metabolism in APP/PS1 Mice.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Mind the Gap: Mapping Mass Spectral Databases in Genome-Scale Metabolic Networks Reveals Poorly Covered Areas.Metabolites · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The microbial secondary metabolome encompasses great synthetic diversity, empowering microbes to tune their chemical responses to changing microenvironments. Traditional metabolomics methods are ill-equipped to probe a wide variety of environments or environmental dynamics. Here we introduce a class of microscale culture platforms to analyse chemical diversity of fungal and bacterial secondary metabolomes. By leveraging stable biphasic interfaces to integrate microculture with small molecule isolation via liquid-liquid extraction, we enable metabolomics-scale analysis using mass spectrometry. This platform facilitates exploration of culture microenvironments (including rare media typically inaccessible using established methods), unusual organic solvents for metabolite isolation and microbial mutants. Utilizing Aspergillus, a fungal genus known for its rich secondary metabolism, we characterize the effects of culture geometry and growth matrix on secondary metabolism, highlighting the potential use of microscale systems to unlock unknown or cryptic secondary metabolites for natural products discovery. Finally, we demonstrate the potential for this class of microfluidic systems to study interkingdom communication between fungi and bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.