ArticleArchives of dermatological research2016
Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition.
Article in Archives of dermatological research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals.Scientific reports · 2021Trial
- Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body.Nature biotechnology · 2026Article
- A Possible Role of Mycobiome in the Pathophysiology of Acne: Structured Narrative Review and Perspectives.Experimental dermatology · 2026Review
- Review
- Advances in Scalp Microbiome Research: Molecular Insights into the Metabolism-Inflammation-Barrier Axis and Dandruff Pathogenesis.Molecules (Basel, Switzerland) · 2026Review
- Clinical Efficacy and Scalp Microbiome Changes Induced by AMPamide-Containing Shampoo in Patients With Seborrheic Dermatitis.Annals of dermatology · 2026Article
- Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study.Allergy · 2026Article
- Microbiological diagnosis of the scalp and hair in 20-40 year olds - preliminary studies.Open life sciences · 2026Review
- A Selenium Disulfide-Based Shampoo Is Beneficial for Dandruff Management and Rebalancing the Scalp Microbiome of Subjects of Any Hair Type.Skin appendage disorders · 2025Article
- Scalp Microbiome Dynamics Can Contribute to the Clinical Effect of a Novel Antiseborrheic Dermatitis Shampoo Containing Patented Antifungal Actives: A Randomized Controlled Study.Dermatology and therapy · 2025Article
- A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.Skin appendage disorders · 2024Article
- Prevalence and associated factors for isolated Malassezia species in patients with Dandruff in Mekelle City, Tigrai, Ethiopia.BMC research notes · 2024Article
- New Topicals to Support a Healthy Scalp While Preserving the Microbiome: A Report of Clinical andThe Journal of clinical and aesthetic dermatology · 2023Article
- Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff.Acta dermato-venereologica · 2023Article
- Significance of Singlet Oxygen Molecule in Pathologies.International journal of molecular sciences · 2023Review
- Continuous clinical improvement of mild-to-moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide-based shampoo after an initial treatment with ketoconazole.Journal of cosmetic dermatology · 2022Article
- Targeted Delivery of Zinc Pyrithione to Skin Epithelia.International journal of molecular sciences · 2021Review
- Host Responses in anFrontiers in cellular and infection microbiology · 2020Article
- Review
- Malassezia furfur promoting growth of Staphylococcus epidermidis by increasing pH when cultured in a lipid-free environment.Chinese medical journal · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dandruff is a common but complex disorder with three major contributing factors: (1) individual predisposition, (2) scalp sebum and (3) Malassezia yeast colonization. To obtain further insights into the role of sebum in dandruff biogenesis, we analyzed scalp lipid species in a cohort of ten dandruff-free (control) and ten dandruff-afflicted volunteers by gas chromatography coupled to mass spectrometry. Lipid peroxidation levels and biochemical markers of oxidative stress were also assessed. Squalene, a major sebum component, was significantly more peroxidized in dandruff-affected scalps, resulting in significantly higher ratios of squalene monohydroperoxide (SQOOH)/squalene. This was observed when comparing dandruff-affected zones of dandruff subjects to both their non-affected zones and control subjects. In addition, other biomarkers such as malondialdehyde indicated that oxidative stress levels were raised on dandruff scalps. Surprisingly, differences regarding either free or bound fatty acids were fairly rare and minor. Certain novel findings, especially squalene peroxidation levels, were then confirmed in a validation cohort of 24 dandruff-affected subjects, by comparing dandruff-affected and non-dandruff zones from the same individuals. As SQOOH can induce both keratinocyte inflammatory responses and hyperproliferation in vitro, we hypothesized that increased SQOOH could be considered as a new etiological dandruff factor via its ability to impair scalp barrier function. Our results also indicated that Malassezia could be a major source of squalene peroxidation on the scalp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.