ArticleScientific reports2016
Introducing Discrete Frequency Infrared Technology for High-Throughput Biofluid Screening.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Combining quantum cascade lasers and plasmonic metasurfaces to monitorNanophotonics (Berlin, Germany) · 2025Article
- Exploring Feature Selection with Deep Learning for Kidney Tissue Microarray Classification Using Infrared Spectral Imaging.Bioengineering (Basel, Switzerland) · 2025Article
- Early Mortality Prediction in Intensive Care Unit Patients Based on Serum Metabolomic Fingerprint.International journal of molecular sciences · 2024Article
- Plasma versus Serum Analysis by FTIR Spectroscopy to Capture the Human Physiological State.Biotech (Basel (Switzerland)) · 2022Article
- Label-Free Infrared Spectroscopic Imaging Reveals Heterogeneity of β-Sheet Aggregates in Alzheimer's Disease.The journal of physical chemistry letters · 2021Article
- Molecular Origin of Blood-Based Infrared Spectroscopic Fingerprints*.Angewandte Chemie (International ed. in English) · 2021Article
- Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review.Applied spectroscopy · 2018Review
- Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections.Scientific reports · 2018Article
- Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging.The Analyst · 2018Article
- Infrared Spectroscopic Imaging Advances as an Analytical Technology for Biomedical Sciences.Analytical chemistry · 2018Review
- Spectroscopic imaging of biomaterials and biological systems with FTIR microscopy or with quantum cascade lasers.Analytical and bioanalytical chemistry · 2017Article
- Infrared spectroscopic imaging detects chemical modifications in liver fibrosis due to diabetes and disease.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate early diagnosis is critical to patient survival, management and quality of life. Biofluids are key to early diagnosis due to their ease of collection and intimate involvement in human function. Large-scale mid-IR imaging of dried fluid deposits offers a high-throughput molecular analysis paradigm for the biomedical laboratory. The exciting advent of tuneable quantum cascade lasers allows for the collection of discrete frequency infrared data enabling clinically relevant timescales. By scanning targeted frequencies spectral quality, reproducibility and diagnostic potential can be maintained while significantly reducing acquisition time and processing requirements, sampling 16 serum spots with 0.6, 5.1 and 15% relative standard deviation (RSD) for 199, 14 and 9 discrete frequencies respectively. We use this reproducible methodology to show proof of concept rapid diagnostics; 40 unique dried liquid biopsies from brain, breast, lung and skin cancer patients were classified in 2.4 cumulative seconds against 10 non-cancer controls with accuracies of up to 90%.
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