ArticlePhysiological reports2016
Assessment of left ventricular hemodynamic forces in healthy subjects and patients with dilated cardiomyopathy using 4D flow MRI.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Evaluation of intraventricular flow by multimodality imaging: a review and meta-analysis.Cardiovascular ultrasound · 2021Pooled it
- The role of Cardiac Magnetic Resonance (CMR) in the diagnosis of cardiomyopathy: A systematic review.Malawi medical journal : the journal of Medical Association of Malawi · 2019Pooled it
- The role of cardiac magnetic resonance (CMR) in the diagnosis of cardiomyopathy: A systematic review.Malawi medical journal : the journal of Medical Association of Malawi · 2018Pooled it
- Clinical applications of intra-cardiac four-dimensional flow cardiovascular magnetic resonance: A systematic review.International journal of cardiology · 2017Pooled it
- Ultrasound-based haemodynamic force trajectories in a murine model of reversible pressure overload.The Journal of physiology · 2026Article
- Apical hypercontractility mitigates impaired diastolic filling and lower intraventricular haemodynamic forces in human bed rest.Experimental physiology · 2026Article
- Cardiac magnetic resonance imaging in the assessment of cardiac injury and toxicity from cancer-related chemotherapy.Pediatric radiology · 2025Review
- Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults.Scientific reports · 2025Article
- Dilated cardiomyopathy evaluation with Imagenomics: combining multimodal cardiovascular imaging and genetics.ESC heart failure · 2025Review
- Intracardiac fluid dynamic analysis: available techniques and novel clinical applications.BMC cardiovascular disorders · 2024Review
- Differences in cardiac mechanics assessed by left ventricular hemodynamic forces in athletes and patients with hypertension.Scientific reports · 2024Article
- Flow inefficiencies in non-obstructive HCM revealed by kinetic energy and hemodynamic forces on 4D-flow CMR.European heart journal. Imaging methods and practice · 2024Article
- Evaluation of left ventricular blood flow kinetic energy in patients with acute myocardial infarction by 4D Flow MRI: a preliminary study.BMC medical imaging · 2024Article
- Current Insights and Novel Cardiovascular Magnetic Resonance-Based Techniques in the Prognosis of Non-Ischemic Dilated Cardiomyopathy.Journal of clinical medicine · 2024Review
- Unravelling the intricacies of left ventricular haemodynamic forces: age and gender-specific normative values assessed by cardiac MRI in healthy adults.European heart journal. Cardiovascular Imaging · 2024Article
- Sizing SGLT2 Inhibitors Up: From a Molecular to a Morpho-Functional Point of View.International journal of molecular sciences · 2023Review
- Hemodynamic forces from 4D flow magnetic resonance imaging predict left ventricular remodeling following cardiac resynchronization therapy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- CMR-derived left ventricular intraventricular pressure gradients identify different patterns associated with prognosis in dilated cardiomyopathy.European heart journal. Cardiovascular Imaging · 2023Article
- Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis.European heart journal. Cardiovascular Imaging · 2023Article
- Evaluation of left ventricular blood flow kinetic energy in patients with hypertension by four-dimensional flow cardiovascular magnetic resonance imaging: a preliminary study.European radiology · 2023Article
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4 authors.
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Abstract
We hypothesized that the direction of global left ventricular (LV) hemodynamic forces during diastolic filling are concordant with the main flow axes in normal LVs, but that this pattern would be altered in dilated and dysfunctional LVs. Therefore, we aimed to assess the LV hemodynamic filling forces in a group of healthy subjects and compare them to the results from a group of patients with dilated cardiomyopathy (DCM). Ten healthy subjects and 10 DCM patients were enrolled. Morphological short- (SAx) and long-axis (LAx) images and 4D flow MRI data were acquired at 1.5T. The LV pressure gradients were computed from the 4D flow data using the Navier-Stokes equations. By integrating the pressure gradients over the LV volume at each time frame, the magnitude and direction of the global hemodynamic force was calculated over the cardiac cycle. The hemodynamic forces acting in the SAx- and LAx-directions were used to calculate the "SAx-max/LAx-max"-ratio for the early (E-wave) and late (A-wave) diastolic filling. In the LAx-plane, the temporal progression of the hemodynamic force followed a consistent pattern in the healthy subjects. The "SAx-max/LAx-max"-ratio was significantly larger at both E-wave (0.53 ± 0.15 vs. 0.23 ± 0.12, P < 0.0001) and A-wave (0.44 ± 0.21 vs. 0.26 ± 0.09, P < 0.03) in the DCM patients compared to the healthy subjects. 4D flow MRI data allow quantification of LV hemodynamic forces acting on the LV myocardial wall. The LV hemodynamic filling forces showed a similar temporal progression among healthy subjects, whereas DCM patients had forces that were more heterogeneous in their direction and magnitude during diastole.
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