ReviewThe journal of physiological sciences : JPS2016
Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor.
Review in The journal of physiological sciences : JPS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 80 citations in OpenAlex.
- Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.Inflammopharmacology · 2026Review
- Does Heat-Induced Activation of Mast Cells Contribute to Elevated Temperature-Induced Male Infertility?Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Mechanosensing of Shear Stress and Uterine Spiral Artery Remodeling by Invasive Trophoblasts in Early Pregnancy.International journal of molecular sciences · 2025Review
- Advances in the Study for Modulators of Transient Receptor Potential Vanilloid (TRPV) Channel Family.Current topics in medicinal chemistry · 2025Review
- Mast Cells as a Component of Spermatogonial Stem Cells' Microenvironment.International journal of molecular sciences · 2024Review
- TRPV4 activation by core body temperature has multimodal functions in the central nervous system.The journal of physiological sciences : JPS · 2024Review
- Description and functional validation of human enteroendocrine cell sensors.Science (New York, N.Y.) · 2024Article
- Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Deregulated Long Non-Coding RNAs (lncRNA) as Promising Biomarkers in Hidradenitis Suppurativa.Journal of clinical medicine · 2024Article
- TRPV Channels in Osteoarthritis: A Comprehensive Review.Biomolecules · 2024Review
- Investigation of local stimulation effects of embedding PGLA at Zusanli (ST36) acupoint in rats based on TRPV2 and TRPV4 ion channels.Frontiers in neuroscience · 2024Article
- TRPV2, a novel player in the human ovary and human granulosa cells.Molecular human reproduction · 2023Article
- Temperature-Dependent Effects of Eicosapentaenoic Acid (EPA) on Browning of Subcutaneous Adipose Tissue in UCP1 Knockout Male Mice.International journal of molecular sciences · 2023Article
- TRPA1/M8 agonists upregulate ciliary beating through the pannexin-1 channel in the human nasal mucosa.Molecular biology reports · 2023Article
- Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated CaMolecular cell · 2023Article
- Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.JCI insight · 2022Article
- Review
- Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation.Biochemistry and biophysics reports · 2021Article
- Long-Term Sequelae of Frostbite-A Scoping Review.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review provides a summary of the physiological significance of the TRPV2 ion channel. While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can also act as a mechanosensor in embryonic neurons or adult myenteric neurons. Here, we summarize the newly characterized functions of TRPV2, including the research progress that has been made toward our understanding of TRPV2 physiology, and discuss other recent data pertaining to TRPV2. It is thought that TRPV2 may be an important drug target based on its broad expression patterns and important physiological roles. The possible associations between diseases and TRPV2 are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.