ArticleScientific reports2016
Grain-rich diets altered the colonic fermentation and mucosa-associated bacterial communities and induced mucosal injuries in goats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 94 citations in OpenAlex.
- Subacute ruminal acidosis in high-producing dairy cows: an integrated diet-microbiota-epithelium-host framework for diagnosis and nutritional management.Journal of animal science and biotechnology · 2026Review
- Effects of dietary tannic acid and antimicrobial peptide on growth performance, immune response, antioxidant capacity, and cecal microbiota in White Pekin ducks up to 21 days of age.Tropical animal health and production · 2026Article
- Plant extracts to enhancing intestinal barrier function in fattening lambs: review.Animal bioscience · 2026Article
- Comparative Analysis of Gut Bacterial Communities in Fish and Shellfish of Great Himalayan River System.Indian journal of microbiology · 2025Article
- Effect of different fermentation substrates on rumen microorganisms and microbe-derived extracellular vesicles (EVs).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Effects of different fiber levels of energy feeds on rumen fermentation and the microbial community structure of grazing sheep.BMC microbiology · 2025Article
- Multi-Omics Analysis Reveals the Negative Effects of High-Concentrate Diets on the Colonic Epithelium of Dumont Lambs.Animals : an open access journal from MDPI · 2025Article
- Impact of oat grain supplementation on growth performance, rumen microbiota, and fatty acid profiles in Hu sheep.Frontiers in microbiology · 2025Article
- Association of litter size with the ruminal microbiome structure and metabolomic profile in goats.Scientific reports · 2024Article
- Castration alters the ileum microbiota of Holstein bulls and promotes beef flavor compounds.BMC genomics · 2024Article
- Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant.Microbiome · 2024Article
- Effects of Noni (Animals : an open access journal from MDPI · 2023Article
- Effects of a High-Concentrate Diet on the Blood Parameters and Liver Transcriptome of Goats.Animals : an open access journal from MDPI · 2023Article
- Dietary spirulina supplementation modifies rumen development, fermentation and bacteria composition in Hu sheep when consuming high-fat dietary.Frontiers in veterinary science · 2023Article
- Feedlot performance, rumen and cecum morphometrics of Nellore cattle fed increasing levels of diet starch containing a blend of essential oils and amylase or monensin.Frontiers in veterinary science · 2023Article
- Dietary L-Arginine or N-Carbamylglutamate Alleviates Colonic Barrier Injury, Oxidative Stress, and Inflammation by Modulation of Intestinal Microbiota in Intrauterine Growth-Retarded Suckling Lambs.Antioxidants (Basel, Switzerland) · 2022Article
- Dynamics Changes of the Fecal Bacterial Community Fed Diets with Different Concentrate-to-Forage Ratios in Qinghai Yaks.Animals : an open access journal from MDPI · 2022Article
- Differential Responses of Digesta- and Mucosa-Associated Jejunal Microbiota of Hu Sheep to Pelleted and Non-Pelleted High-Grain Diets.Animals : an open access journal from MDPI · 2022Article
- Replacement of Maize Silage and Soyabean Meal with Mulberry Silage in the Diet of Hu Lambs on Growth, Gastrointestinal Tissue Morphology, Rumen Fermentation Parameters and Microbial Diversity.Animals : an open access journal from MDPI · 2022Article
- β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remarkably little information is available about the impact of high-grain (HG) feeding on colonic mucosa-associated bacteria and mucosal morphology. In the present study, 12 male goats were randomly assigned to either a hay diet (n = 6) or an HG diet (65% grain; n = 6) to characterise the changes in the composition of the bacterial community in colonic mucosa and the mucosal morphology of the colon. The results showed that HG feeding decreased the colonic pH and increased the concentrations of total short chain fatty acids and lipopolysaccharides in colonic digesta. The principal coordinate analysis results showed that the HG diet altered the colonic mucosal bacterial communities, with an increase in the abundance of genus Blautia and a decrease in the abundance of genera Bacillus, Enterococcus, and Lactococcus. The HG-fed goats showed sloughing of the surface layer epithelium, intercellular tight junction erosion, cell mitochondrial damage, and upregulation of the relative mRNA expression of IL-2 and IFN-γ in colonic mucosa. Collectively, our data indicate that HG feeding induced changes in colonic mucosal morphology and cytokines expression that might be caused by excessive fermentation and dramatic shifts in the bacterial populations in the colon.
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