Evidence map›Paper›PMID 26841306›Full record

ReviewClinical pharmacology and therapeutics2016

Epigenetics and addiction.

J L Cadet, M T McCoy, S Jayanthi

Open access · greenAbstract readReview
In one paragraph

Review in Clinical pharmacology and therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Neurogenetics and Epigenetics of Loneliness.Psychology research and behavior management · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue".Current behavioral neuroscience reports · 2016
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J L CadetMolecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
M T McCoyMolecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
S JayanthiMolecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
National Institute on Drug Abuse · USNational Institutes of Health · US

Funding

Serial analysis of gene expression in the rat striatum following methamphetamineZ01DA000495 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI CADET, JEAN LUD · 2007 to 2008
$1.1M
Intramural NIH HHS Z01 DA000495
6 · The paper itself

Abstract

Addictions are public health menaces. However, despite advances in addiction research, the cellular or molecular mechanisms that cause transition from recreational use to addiction remain to be elucidated. We have recently suggested that addiction may be secondary to long-term epigenetic modifications that determine the clinical course of substance use disorders. A better understanding of epigenetic mechanisms in animal models that mimic human conditions should help to usher in a new area of drug development against addiction.

Indexed as

Drug DesignAnimalsDisease Models, AnimalEpigenesis, GeneticHumansPublic HealthSubstance-Related Disorders

Identifiers

PMID26841306
PMCPMC8252834
OpenAlexW2265556546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.