Evidence map›Paper›PMID 26841063›Full record

ReviewThe European journal of neuroscience2016

The external globus pallidus: progress and perspectives.

Daniel J Hegeman, Ellie S Hong, Vivian M Hernández, C Savio Chan

Open access · greenAbstract readReview
In one paragraph

Review in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cognitive functions of the GPe.Trends in neurosciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Restoring Compromised ClThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel J HegemanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Ellie S HongDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Vivian M HernándezDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
C Savio ChanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Northwestern University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
SYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2003 to 2018
$19.2M
Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
Investigation of Pallidal Neurons in Motor InhibitionR56NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2022 to 2022
$536k
NIGMS NIH HHS T32 GM008152NINDS NIH HHS P50 NS047085NINDS NIH HHS R01 NS069777NINDS NIH HHS R56 NS069777
6 · The paper itself

Abstract

The external globus pallidus (GPe) of the basal ganglia is in a unique and powerful position to influence processing of motor information by virtue of its widespread projections to all basal ganglia nuclei. Despite the clinical importance of the GPe in common motor disorders such as Parkinson's disease, there is only limited information about its cellular composition and organizational principles. In this review, recent advances in the understanding of the diversity in the molecular profile, anatomy, physiology and corresponding behaviour during movement of GPe neurons are described. Importantly, this study attempts to build consensus and highlight commonalities of the cellular classification based on existing but contentious literature. Additionally, an analysis of the literature concerning the intricate reciprocal loops formed between the GPe and major synaptic partners, including both the striatum and the subthalamic nucleus, is provided. In conclusion, the GPe has emerged as a crucial node in the basal ganglia macrocircuit. While subtleties in the cellular makeup and synaptic connection of the GPe create new challenges, modern research tools have shown promise in untangling such complexity, and will provide better understanding of the roles of the GPe in encoding movements and their associated pathologies.

Indexed as

MovementAnimalsBasal GangliaBrain DiseasesGlobus PallidusHumansNeural PathwaysNeuronsSubthalamic Nucleusarkypallidal neuronsNpas1Parkinson's diseaseparvalbuminprototypic neurons

Identifiers

PMID26841063
PMCPMC4874844
OpenAlexW2273491821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.