Evidence map›Paper›PMID 26840837›Full record

ArticleRespiratory physiology & neurobiology2016

Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice.

R R Dhingra, M Dutschmann, T E Dick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Breathing disturbances in Rett syndrome.Handbook of clinical neurology · 2022
    Review
  3. Review
  4. Countermeasures for Preventing and Treating Opioid Overdose.Clinical pharmacology and therapeutics · 2021
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

R R DhingraDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
M DutschmannFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
T E DickDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA. Electronic address: thomas.dick@case.edu.
SleepMed · USThe University of Melbourne · AU

Funding

SLEEP MEDICINE NEUROBIOLOGY AND EPIDEMIOLOGYT32HL007913 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2020
$3.2M
Modeling of Pathogenic Breathing Pattern Dysregulation in Cardiopulmonary DiseaseR33HL087377 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI DICK, THOMAS E · 2008 to 2010
$961k
NHLBI NIH HHS R33 HL087377NHLBI NIH HHS T32 HL007913
6 · The paper itself

Abstract

The neurotransmitter serotonin (5HT) acting via 5HT1a receptors (5HT1aR) is a potent determinant of respiratory rhythm variability. Here, we address the 5HT1aR-dependent control of respiratory rhythm variability in C57BL6/J mice. Using the in situ perfused preparation, we compared the effects of systemic versus focal blockade of 5HT1aRs. Blocking 5HT1aRs in the Kölliker-Fuse nucleus (KFn) increased the occurrence of spontaneous apneas and accounted for the systemic effects of 5HT1aR antagonists. Further, 5HT1aRs of the KFn stabilized the respiratory rhythm's response to arterial chemoreflex perturbations; reducing the recovering time, e.g., the latency to return to the baseline pattern. Together, these results suggest that the KFn regulates both intrinsic and sensory determinants of respiratory rhythm variability.

Indexed as

AnimalsApneaChemoreceptor CellsCyclohexanesFemaleKolliker-Fuse NucleusMembrane PotentialsMice, 129 StrainMice, Inbred BALB CMice, Inbred C57BLPeripheral Nervous System AgentsPhrenic NervePiperazinesReceptor, Serotonin, 5-HT1AReflexRespirationCyclohexanesPeripheral Nervous System AgentsPiperazinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AntagonistsSodium CyanideWAY 101363Control of breathingGain controlKölliker-Fuse nuclei (KFN)Mecp2-deficient miceRett SyndromeSerotonin (5-HT)Variability

Identifiers

PMID26840837
PMCPMC4909512
OpenAlexW2261354623

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.