ArticleBiophysical journal2016
Modeling the Overproduction of Ribosomes when Antibacterial Drugs Act on Cells.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- A mismatch between slow protein synthesis and fast environmental fluctuations determines tradeoffs in bacterial proteome allocation strategies.bioRxiv : the preprint server for biology · 2025Article
- Stenotrophomonas maltophilia impedes Bacillus biocontrol of tomato wilt disease by degrading its lipopeptide antibiotics.The ISME journal · 2025Article
- Bioactive exometabolites drive maintenance competition in simple bacterial communities.mSystems · 2024Article
- A coarse-grained resource allocation model of carbon and nitrogen metabolism in unicellular microbes.Journal of the Royal Society, Interface · 2023Article
- Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments.The ISME journal · 2023Article
- Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia.Royal Society open science · 2022Article
- A bacterial size law revealed by a coarse-grained model of cell physiology.PLoS computational biology · 2020Article
- How Do Cells Adapt? Stories Told in Landscapes.Annual review of chemical and biomolecular engineering · 2020Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria that are subjected to ribosome-inhibiting antibiotic drugs show an interesting behavior: Although the drug slows down cell growth, it also paradoxically increases the cell's concentration of ribosomes. We combine our earlier nonlinear model of the energy-biomass balance in undrugged Escherichia coli cells with Michaelis-Menten binding of drugs that inactivate ribosomes. Predictions are in good agreement with experiments on ribosomal concentrations and synthesis rates versus drug concentrations and growth rates. The model indicates that the added drug drives the cell to overproduce ribosomes, keeping roughly constant the level of ribosomes producing ribosomal proteins, an important quantity for cell growth. The model also predicts that ribosomal production rates should increase and then decrease with added drug. This model gives insights into the driving forces in cells and suggests new experiments.
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Registered trials
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