ArticleBiophysical journal2016
Early Folding Events, Local Interactions, and Conservation of Protein Backbone Rigidity.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Revealing the Folding of Single-Chain Polymeric Nanoparticles at the Atomistic Scale by Combining Computational Modeling and X-ray Scattering.ACS macro letters · 2025Article
- Recent Advances in Protein Folding Pathway Prediction through Computational Methods.Current medicinal chemistry · 2024Review
- Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.Chemical reviews · 2022Review
- Online biophysical predictions for SARS-CoV-2 proteins.BMC molecular and cell biology · 2021Article
- The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies.Briefings in bioinformatics · 2021Review
- Interpreting a black box predictor to gain insights into early folding mechanisms.Computational and structural biotechnology journal · 2021Article
- Energy Bilocalization Effect and the Emergence of Molecular Functions in Proteins.Frontiers in molecular biosciences · 2021Article
- The physical origin of rate promoting vibrations in enzymes revealed by structural rigidity.Scientific reports · 2020Article
- StructureDistiller: Structural relevance scoring identifies the most informative entries of a contact map.Scientific reports · 2019Article
- Auto-encoding NMR chemical shifts from their native vector space to a residue-level biophysical index.Nature communications · 2019Article
- Application of an interpretable classification model on Early Folding Residues during protein folding.BioData mining · 2019Article
- Article
- Exploring the Sequence-based Prediction of Folding Initiation Sites in Proteins.Scientific reports · 2017Article
- Observation selection bias in contact prediction and its implications for structural bioinformatics.Scientific reports · 2016Article
- Mapping the Geometric Evolution of Protein Folding Motor.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein folding is in its early stages largely determined by the protein sequence and complex local interactions between amino acids, resulting in lower energy conformations that provide the context for further folding into the native state. We compiled a comprehensive data set of early folding residues based on pulsed labeling hydrogen deuterium exchange experiments. These early folding residues have corresponding higher backbone rigidity as predicted by DynaMine from sequence, an effect also present when accounting for the secondary structures in the folded protein. We then show that the amino acids involved in early folding events are not more conserved than others, but rather, early folding fragments and the secondary structure elements they are part of show a clear trend toward conserving a rigid backbone. We therefore propose that backbone rigidity is a fundamental physical feature conserved by proteins that can provide important insights into their folding mechanisms and stability.
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