ArticlePloS one2016
Host-Parasite Interactions and Purifying Selection in a Microsporidian Parasite of Honey Bees.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Meta-Analysis and Experimental Evidence Reveal No Impact of Nosema ceranae Infection on Honeybee Carbohydrate Consumption.Microbial ecology · 2025Pooled it
- nce-miR-12220 is a vital regulator for microsporidian to infect honeybee via positive modulation of ATP-A and γ-tubulin genes.PLoS pathogens · 2026Article
- Article
- Article
- Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees.Nature communications · 2023Article
- Signatures of Adaptation, Constraints, and Potential Redundancy in the Canonical Immune Genes of a Key Pollinator.Genome biology and evolution · 2023Article
- Comparative Transcriptome Investigation ofInsects · 2022Article
- Transgenerational genomic analyses reveal allelic oscillation and purifying selection in a gut parasiteFrontiers in microbiology · 2022Article
- Nosema apis and N. ceranae Infection in Honey bees: A Model for Host-Pathogen Interactions in Insects.Experientia supplementum (2012) · 2022Article
- In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian.Frontiers in microbiology · 2022Article
- Immune Response of Eastern Honeybee Worker toInsects · 2021Article
- Effect of Immune Inducers onInsects · 2020Article
- Impact of Mixed Infections of Gut ParasitesInsects · 2020Article
- Genome-Wide Identification of Long Non-Coding RNAs and Their Regulatory Networks Involved inInsects · 2019Article
- Encephalitozoon cuniculi and Vittaforma corneae (Phylum Microsporidia) inhibit staurosporine-induced apoptosis in human THP-1 macrophages in vitro.Parasitology · 2019Article
- Spore load and immune response of honey bees naturally infected by Nosema ceranae.Parasitology research · 2017Article
- Honeybees show an increased preference for dietary alcohol when parasitized.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the mechanisms of Nosema ceranae parasitism, we deep-sequenced both honey bee host and parasite mRNAs throughout a complete 6-day infection cycle. By time-series analysis, 1122 parasite genes were significantly differently expressed during the reproduction cycle, clustering into 4 expression patterns. We found reactive mitochondrial oxygen species modulator 1 of the host to be significantly down regulated during the entire infection period. Our data support the hypothesis that apoptosis of honey bee cells was suppressed during infection. We further analyzed genome-wide genetic diversity of this parasite by comparing samples collected from the same site in 2007 and 2013. The number of SNP positions per gene and the proportion of non-synonymous substitutions per gene were significantly reduced over this time period, suggesting purifying selection on the parasite genome and supporting the hypothesis that a subset of N. ceranae strains might be dominating infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.