ArticleAlzheimer disease and associated disorders
The Relationship Between Mobility Dysfunction Staging and Global Cognitive Performance.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Sex Differences in the Association Between Physical Functioning and Cognition in Two Central European Populations.European journal of neurology · 2025Article
- Links across disabilities: unveiling associations between functional domains.BMC public health · 2024Article
- Gait and/or balance disturbances associated with Alzheimer's dementia among older adults with amnestic mild cognitive impairment: A longitudinal observational study.Journal of advanced nursing · 2023Observational
- Exploring Reasons for Differential Vulnerability and Alzheimer's Disease Risk in Racial and Ethnic Minorities.Journal of Alzheimer's disease : JAD · 2023Article
- Differences in Characteristics between Older Adults Meeting Criteria for Sarcopenia and Possible Sarcopenia: From Research to Primary Care.International journal of environmental research and public health · 2022Article
- The Brain Health Platform: Combining Resilience, Vulnerability, and Performance to Assess Brain Health and Risk of Alzheimer's Disease and Related Disorders.Journal of Alzheimer's disease : JAD · 2022Article
- Fall prediction in neurological gait disorders: differential contributions from clinical assessment, gait analysis, and daily-life mobility monitoring.Journal of neurology · 2021Article
- A Modified CAIDE Risk Score as a Screening Tool for Cognitive Impairment in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Dual-Task Training Affect Cognitive and Physical Performances and Brain Oscillation Ratio of Patients With Alzheimer's Disease: A Randomized Controlled Trial.Frontiers in aging neuroscience · 2020Article
- The Effect of Sociodemographics, Physical Function, and Mood on Dementia Screening in a Multicultural Cohort.Clinical interventions in aging · 2020Article
- Article
- Article
- Examining the Association between Life-Space Mobility and Cognitive Function in Older Adults: A Systematic Review.Journal of aging research · 2019Review
- Muscle profile and cognition in patients with Alzheimer's disease dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Prevention of Alzheimer's Disease: Lessons Learned and Applied.Journal of the American Geriatrics Society · 2017Article
- Older People's Experiences of Mobility and Mood in an Urban Environment: A Mixed Methods Approach Using Electroencephalography (EEG) and Interviews.International journal of environmental research and public health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo assess the relationship and the directionality between mobility and cognitive performance.
methodA cross-sectional analysis of a racially/ethnically diverse sample of 327 community-dwelling adults (mean age=68.9±9.9 y; range, 40 to 100 y) categorized as having no mobility dysfunction, upper-extremity (UE) impairment, lower-extremity (LE) impairment, or mobility limitation (both UE and LE impairments), and compared by global cognition with multiple hierarchical linear regression adjusted for sociodemographic, health, and mood factors. A bootstrapping mediation analysis investigated the directionality of the mobility-cognition association.
resultsLE (Est.=-2.95±0.77, P=0.001) but not UE impairment (Est.=-1.43±1.05, P=0.175) was associated with a poorer global cognitive performance/impairment. The presence of mobility limitation had the strongest effect on cognition (Est.=-3.78±1.09, P<0.001) adjusting for sociodemographic factors, body composition, comorbidities, and mood. Mediation analysis indicated that the relationship between cognition and mobility likely operates in both directions. DISCUSSION: The association between cognitive function and mobility follows a dose-response pattern in which the likelihood of poor global cognition increases with the progression of mobility dysfunction, with evidence that LE impairments may be better indicators of an impaired cognitive status than UE impairments. Using brief, valid tools to screen older patients for early signs of mobility dysfunction, especially when the LE is affected, is feasible, and may provide the first detectable stage of future cognitive impairment and provide actionable steps for interventions to improve performance, reduce burden, and prevent the development of physical disability and loss of independence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.