Evidence map›Paper›PMID 26840503›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2016

DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior.

Cathal J Kearney, Christopher R Lucas, Fergal J O'Brien, Carlos E Castro

Open access · greenAbstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
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  7. Plugging synthetic DNA nanoparticles into the central dogma of life.Chemical communications (Cambridge, England) · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Engineered Tools to Study Intercellular Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  18. Article
  19. Smart cancer therapy with DNA origami.Nature biotechnology · 2018
    Article
  20. Engineering Cell Surface Function with DNA Origami.Advanced materials (Deerfield Beach, Fla.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Cathal J KearneyDepartment of Anatomy, Tissue Engineering Research Group and Advanced Materials and Bioengineering Research Center, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland.
Christopher R LucasDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Fergal J O'BrienDepartment of Anatomy, Tissue Engineering Research Group and Advanced Materials and Bioengineering Research Center, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland.
Carlos E CastroDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Advanced Materials and BioEngineering Research · IEThe Ohio State University · US

Funding

SPORE Leukemia Tissue BankP50CA140158 · NCI · OHIO STATE UNIVERSITY · PI BLOOMFIELD, CLARA D · 2009 to 2013
$11.2M
ONOCOLOGY TRAINING GRANTT32CA009338 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C., POLLOCK, RAPHAEL E. · 1985 to 2018
$8.3M
NCI NIH HHS P50 CA140158NCI NIH HHS T32 CA009338
6 · The paper itself

Abstract

DNA origami is a DNA-based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA-origami field since its inception several years ago are reviewed with a focus on how these DNA-nanodevices can be designed to interact with cells to direct or probe their behavior.

Indexed as

DNANanoporesNanostructuresNanotechnologyNucleic Acid ConformationOligonucleotidesDNAOligonucleotidesbiosensingDNA origamidrug deliverynanoparticlesnanopores

Identifiers

PMID26840503
PMCPMC4945425
OpenAlexW2253264005

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.