ArticlePloS one2016
Alterations of the Ileal and Colonic Mucosal Microbiota in Canine Chronic Enteropathies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs.Journal of veterinary internal medicine · 2026Pooled it
- Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease.Gut microbes · 2017Trial
- Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: a randomised trial.BMC veterinary research · 2016Trial
- Gut Microbiome Disruption in Shelter Cats with Feline Panleukopenia: Virome Co-Detection and Enteric Dysbiosis.Biology · 2026Review
- Effects of High-Dose Prednisone on the Gastrointestinal Microbiota of Healthy Dogs.Veterinary sciences · 2025Article
- The alleviating effects and mechanisms ofFrontiers in veterinary science · 2025Article
- Abundance of bacteria and histopathologic findings in the small intestinal mucosa of dogs with chronic inflammatory enteropathies.PloS one · 2025Article
- Large intestinal nutritional and physicochemical parameters from different dog sizes reshape canine microbiota structure and functionsBioengineered · 2024Article
- Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations.Microorganisms · 2024Review
- Updating the Classification of Chronic Inflammatory Enteropathies in Dogs.Animals : an open access journal from MDPI · 2024Review
- Fluorescent In Situ Hybridization for the Detection of Intracellular Bacteria in Companion Animals.Veterinary sciences · 2024Review
- Circadian Rhythm Perturbation Aggravates Gut Microbiota Dysbiosis in Dextran Sulfate Sodium-Induced Colitis in Mice.Nutrients · 2024Article
- Modulation of In Vitro Macrophage Responses via Primary and Secondary Bile Acids in Dogs.Animals : an open access journal from MDPI · 2023Article
- Isolation, Identification and Antimicrobial Resistance Analysis of Canine Oral and IntestinalInternational journal of molecular sciences · 2023Article
- Analysis of fecal microbial profiles in dogs with intestinal lymphangiectasia.The Journal of veterinary medical science · 2023Article
- Synbiotic-IgY Therapy Modulates the Mucosal Microbiome and Inflammatory Indices in Dogs with Chronic Inflammatory Enteropathy: A Randomized, Double-Blind, Placebo-Controlled Study.Veterinary sciences · 2022Article
- GWAS-associated bacteria and their metabolites appear to be causally related to the development of inflammatory bowel disease.European journal of clinical nutrition · 2022Article
- The Contribution of Gut Microbiota and Endothelial Dysfunction in the Development of Arterial Hypertension in Animal Models and in Humans.International journal of molecular sciences · 2022Review
- Article
- Nonpharmacological Treatment Strategies for the Management of Canine Chronic Inflammatory Enteropathy-A Narrative Review.Veterinary sciences · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon.
aimTo investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls.
methodsTissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by fluorescence in situ hybridization (FISH) on a quantifiable basis.
resultsThe ileal and colonic mucosa of healthy dogs and dogs with CE is predominantly colonized by bacteria localized to free and adherent mucus compartments. CE dogs harbored more (P < 0.05) mucosal bacteria belonging to the Clostridium-coccoides/Eubacterium rectale group, Bacteroides, Enterobacteriaceae, and Escherichia coli versus controls. Within the CE group, IBD dogs had increased (P < 0.05) Enterobacteriaceae and E. coli bacteria attached onto surface epithelia or invading within the intestinal mucosa. Bacterial invasion with E. coli was observed in the ileal and colonic mucosa of dogs with GC (P < 0.05). Dogs with intestinal neoplasia had increased (P < 0.05) adherent (total bacteria, Enterobacteriaceae, E. coli) and invasive (Enterobacteriaceae, E. coli, and Bacteroides) bacteria in biopsy specimens. Increased numbers of total bacteria adherent to the colonic mucosa were associated with clinical disease severity in IBD dogs (P < 0.05).
conclusionPathogenic events in canine CE are associated with different populations of the ileal and colonic mucosal microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.