Evidence map›Paper›PMID 26840348›Full record

ArticleAmerican journal of respiratory and critical care medicine2016

Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors.

Lauren E Ferrante, Margaret A Pisani, Terrence E Murphy, Evelyne A Gahbauer, Linda S Leo-Summers, Thomas M Gill

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 3 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
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  11. Article
  12. Age-Specific Prognostic Models for Sepsis-Associated Acute Kidney Injury: A Multicenter Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  13. Observational
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  15. Article
  16. Review
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  18. Health-related social needs before and after critical illness among Medicare beneficiaries.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren E Ferrante1 Section of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0003-1345-1225
Margaret A Pisani1 Section of Pulmonary, Critical Care, and Sleep Medicine and.
Terrence E Murphy2 Section of Geriatrics, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
Evelyne A Gahbauer2 Section of Geriatrics, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
Linda S Leo-Summers2 Section of Geriatrics, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
Thomas M Gill2 Section of Geriatrics, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
Yale University · USSleepMed · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Training Translational Lung Biology and PathobiologyT32HL007778 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog, NAFTALI KAMINSKI · 1994 to 2026
$14.4M
Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related ResearchT32AG019134 · NIA · YALE UNIVERSITY · PI Terri R. Fried · 2001 to 2026
$7.5M
Epidemiology of Disability and Recovery in Older PersonsR37AG017560 · NIA · YALE UNIVERSITY · PI GILL, THOMAS MICHAEL · 2005 to 2014
$7.3M
VULNERABILITY, INTERVENING EVENTS &DISABILITY IN AGINGR01AG017560 · NIA · YALE UNIVERSITY · PI GILL, THOMAS MICHAEL · 2000 to 2025
$7.0M
ACADEMIC LEADERSHIP AWARD IN DISABILITY AND DISABLING DISORDERSK07AG043587 · NIA · YALE UNIVERSITY · PI GILL, THOMAS MICHAEL · 2013 to 2017
$645k
Critical Illness, Disability, and Vulnerability in Older PersonsR03AG050874 · NIA · YALE UNIVERSITY · PI FERRANTE, LAUREN · 2015 to 2016
$250k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T32 HL007778NIA NIH HHS K07 AG043587NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG017560NIA NIH HHS R03 AG050874NIA NIH HHS R37 AG017560NIA NIH HHS T32 AG019134
6 · The paper itself

Abstract

rationaleMost of the 1.4 million older adults who survive the intensive care unit (ICU) annually in the United States face increased disability, but little is known about those who achieve functional recovery.

objectivesOur objectives were twofold: to evaluate the incidence and time to recovery of premorbid function within 6 months of a critical illness and to identify independent predictors of functional recovery among older ICU survivors.

methodsPotential participants included 754 persons aged 70 years or older who were evaluated monthly in 13 functional activities (1998-2012). The analytic sample included 218 ICU admissions from 186 ICU survivors. Functional recovery was defined as returning to a disability count less than or equal to the pre-ICU disability count within 6 months. Twenty-one potential predictors were evaluated for their associations with recovery. MEASUREMENTS AND MAIN

resultsFunctional recovery was observed for 114 (52.3%) of the 218 admissions. In multivariable analysis, higher body mass index (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03-1.12) and greater functional self-efficacy (HR, 1.05; 95% CI, 1.02-1.08), a measure of confidence in performing various activities, were associated with recovery, whereas pre-ICU impairment in hearing (HR, 0.38; 95% CI, 0.22-0.66) and vision (HR, 0.59; 95% CI, 0.37-0.95) were associated with a lack of recovery.

conclusionsAmong older adults who survived an ICU admission with increased disability, pre-ICU hearing and vision impairment were strongly associated with poor functional recovery within 6 months, whereas higher body mass index and functional self-efficacy were associated with recovery. Future research is needed to evaluate whether interventions targeting these factors improve functional outcomes among older ICU survivors.

Indexed as

Intensive Care UnitsRecovery of FunctionAgedAged, 80 and overCritical IllnessFemaleGeriatric AssessmentHumansLongitudinal StudiesMaleSurvivorsTime Factorsfunctional statusintensive careMedicarequality of life

Identifiers

PMID26840348
PMCPMC4970594
OpenAlexW2257426351

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.