Evidence map›Paper›PMID 26840330›Full record

Trial reportNutrients2016

Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome.

Sergej M Ostojic, Marko Stojanovic, Patrik Drid, Jay R Hoffman, Damir Sekulic, Natasa Zenic

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2017
    Pooled it
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  7. Creatine and post-viral fatigue syndrome: an update.Journal of the International Society of Sports Nutrition · 2025
    Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sergej M OstojicFaculty of Sport and Physical Education, University of Novi Sad, Novi Sad 21000, Serbia. sergej.ostojic@chess.edu.rs.
Marko StojanovicFaculty of Sport and Physical Education, University of Novi Sad, Novi Sad 21000, Serbia. marko.stojanovic@chess.edu.rs.
Patrik DridFaculty of Sport and Physical Education, University of Novi Sad, Novi Sad 21000, Serbia. patrikdrid@gmail.com.
Jay R HoffmanDepartment of Educational and Human Sciences, Burnett School of Biomedical Sciences, University of Central Florida, Orlando 32816, FL, USA. jay.hoffman@ucf.edu.
Damir SekulicFaculty of Kinesiology, University of Split, Split 21000, Croatia. dado@kifst.hr.
Natasa ZenicFaculty of Kinesiology, University of Split, Split 21000, Croatia. natasa@kifst.hr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of dietary interventions has been used in the management of chronic fatigue syndrome (CFS), yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. The main aim of this study was to evaluate the effects of orally administered guanidinoacetic acid (GAA) on multidimensional fatigue inventory (MFI), musculoskeletal soreness, health-related quality of life, exercise performance, screening laboratory studies, and the occurrence of adverse events in women with CFS. Twenty-one women (age 39.3 ± 8.8 years, weight 62.8 ± 8.5 kg, height 169.5 ± 5.8 cm) who fulfilled the 1994 Centers for Disease Control and Prevention criteria for CFS were randomized in a double-blind, cross-over design, from 1 September 2014 through 31 May 2015, to receive either GAA (2.4 grams per day) or placebo (cellulose) by oral administration for three months, with a two-month wash-out period. No effects of intervention were found for the primary efficacy outcome (MFI score for general fatigue), and musculoskeletal pain at rest and during activity. After three months of intervention, participants receiving GAA significantly increased muscular creatine levels compared with the placebo group (36.3% vs. 2.4%; p < 0.01). Furthermore, changes from baseline in muscular strength and aerobic power were significantly greater in the GAA group compared with placebo (p < 0.05). Results from this study indicated that supplemental GAA can positively affect creatine metabolism and work capacity in women with CFS, yet GAA had no effect on main clinical outcomes, such as general fatigue and musculoskeletal soreness.

Indexed as

Dietary SupplementsAdultCreatineFatigueFatigue Syndrome, ChronicFemaleGlycineHumansMiddle AgedMusclesMuscle StrengthMusculoskeletal PainPhysical ExertionTreatment OutcomeCreatineGlycineglycocyaminecellular bioenergeticscreatineexercise performancegeneral fatigue

Identifiers

PMID26840330
PMCPMC4772036

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.