ReviewInternational journal of molecular sciences2016
Clinical Genetic Aspects of ASD Spectrum Disorders.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Genetic Testing History in Adults With Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Genetic Counseling Utilization and Experience Among Caregivers of Children With ASD in the United States.Journal of autism and developmental disorders · 2025Article
- Parental Competences and Stress Levels in Mothers of Children with Autism Spectrum Disorders and Children Developing Neurotypically.Journal of clinical medicine · 2024Article
- Microglia heterogeneity in health and disease.FEBS open bio · 2024Review
- Genetic etiology of autism spectrum disorder in the African population: a scoping review.Frontiers in genetics · 2024Article
- Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health.European journal of human genetics : EJHG · 2022Article
- Modern Biomarkers for Autism Spectrum Disorder: Future Directions.Molecular diagnosis & therapy · 2022Article
- Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1Molecular autism · 2022Article
- Article
- Stem Cell Therapies for Cerebral Palsy and Autism Spectrum Disorder-A Systematic Review.Brain sciences · 2021Review
- Comprehensive Genetic Analysis of Non-syndromic Autism Spectrum Disorder in Clinical Settings.Journal of autism and developmental disorders · 2021Article
- Neuronal and glial cell number is altered in a cortical layer-specific manner in autism.Autism : the international journal of research and practice · 2021Article
- Psychometric Properties of the POAGTS: A Tool for Understanding Parents' Perceptions Regarding Autism Spectrum Disorder Genetic Testing.International journal of environmental research and public health · 2021Article
- Pathogenic Yield of Genetic Testing in Autism Spectrum Disorder.Pediatrics · 2020Article
- A de novo frameshift pathogenic variant in TBR1 identified in autism without intellectual disability.Human genomics · 2020Article
- Neuroinflammatory Gene Expression Alterations in Anterior Cingulate Cortical White and Gray Matter of Males With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Genetic Counseling in Neurodevelopmental Disorders.Cold Spring Harbor perspectives in medicine · 2020Review
- Machine learning analysis of exome trios to contrast the genomic architecture of autism and schizophrenia.BMC psychiatry · 2020Article
- Trauma and Autism Spectrum Disorder: Review, Proposed Treatment Adaptations and Future Directions.Journal of child & adolescent trauma · 2019Article
- Brief Report: Pediatrician Perspectives Regarding Genetic Evaluations of Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early presumptions opined that autism spectrum disorder (ASD) was related to the rearing of these children by emotionally-distant mothers. Advances in the 1960s and 1970s clearly demonstrated the biologic basis of autism with a high heritability. Recent advances have demonstrated that specific etiologic factors in autism spectrum disorders can be identified in 30%-40% of cases. Based on early reports newer, emerging genomic technologies are likely to increase this diagnostic yield to over 50%. To date these investigations have focused on etiologic factors that are largely mono-factorial. The currently undiagnosed causes of ASDs will likely be found to have causes that are more complex. Epigenetic, multiple interacting loci, and four dimensional causes (with timing as a variable) are likely to be associated with the currently unidentifiable cases. Today, the "Why" is more important than ever. Understanding the causes of ASDs help inform families of important issues such as recurrence risk, prognosis, natural history, and predicting associated co-morbid medical conditions. In the current era of emerging efforts in "personalized medicine", identifying an etiology will be critical in identifying endo-phenotypic groups and individual variations that will allow for tailored treatment for persons with ASD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.