Evidence map›Paper›PMID 26840230›Full record

Observational studyMuscle & nerve2016

Electrical impedance myography in facioscapulohumeral muscular dystrophy.

Jeffrey M Statland, Chad Heatwole, Katy Eichinger, Nuran Dilek, William B Martens, Rabi Tawil

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. The Value of Imaging and Composition-Based Biomarkers in Duchenne Muscular Dystrophy Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  14. Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019
    Review
  15. Article
  16. Facioscapulohumeral Muscular Dystrophy: Update on Pathogenesis and Future Treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  17. Observational
  18. Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jeffrey M StatlandDepartment of Neurology, University of Kansas Medical Center, 4330 Shawnee Mission Parkway, Ste. 323, Fairway, Kansas, 66205, USA. jstatland@kumc.edu.
Chad HeatwoleDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Katy EichingerDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Nuran DilekDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
William B MartensDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Rabi TawilDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
University of Rochester Medical Center · USUniversity of Kansas Medical Center · US

Funding

UNIVERSITY OF ROCHESTER'S RESEARCH ASSOCIATE ORGANIZATIONUL1RR024160 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$38.7M
EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASET32NS007338 · NINDS · UNIVERSITY OF ROCHESTER · PI ROBERT G. HOLLOWAY, Michael P McDermott · 1990 to 2026
$6.4M
Heartland Institute for Clinical and Translational ResearchKL2TR000119 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$2.5M
Heartland Institute for Clinical and Translational ResearchTL1TR000120 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$549k
Development of a Clinically Relevant Outcome Measure for FSHD Therapeutic TrialsU01AR065119 · NIAMS · UNIVERSITY OF ROCHESTER · PI HEATWOLE, CHAD RYDEL · 2013 to 2015
$509k
NCATS NIH HHS KL2 TR000119NCATS NIH HHS TL1 TR000120NCRR NIH HHS UL1 RR024160NIAMS NIH HHS U01 AR065119NINDS NIH HHS T32 NS007338
6 · The paper itself

Abstract

introductionIn this study we determined the reliability and validity of electrical impedance myography (EIM) in facioscapulohumeral muscular dystrophy (FSHD).

methodsWe performed a prospective study of EIM on 16 bilateral limb and trunk muscles in 35 genetically defined and clinically affected FSHD patients (reliability testing on 18 patients). Summary scores based on body region were derived. Reactance and phase (50 and 100 kHz) were compared with measures of strength, FSHD disease severity, and functional outcomes.

resultsParticipants were mostly men, mean age 53.0 years, and included a full range of severity. Limb and trunk muscles showed good to excellent reliability [intraclass correlation coefficients (ICC) 0.72-0.99]. Summary scores for the arm, leg, and trunk showed excellent reliability (ICC 0.89-0.98). Reactance was the most sensitive EIM parameter to a broad range of FSHD disease metrics.

conclusionsEIM is a reliable measure of muscle composition in FSHD that offers the possibility to serially evaluate affected muscles. Muscle Nerve 54: 696-701, 2016.

Indexed as

Electric ImpedanceAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscular Dystrophy, FacioscapulohumeralMyographyProspective Studieselectrical impedance myographyfacioscapulohumeral muscular dystrophymuscle compositionmuscular dystrophyoutcome measure

Identifiers

PMID26840230
PMCPMC4972708
OpenAlexW2271912728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.