ArticlePloS one2016
Retinoic Acid Specifically Enhances Embryonic Stem Cell Metastate Marked by Zscan4.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- PIM3-AMPK-HDAC4/5 axis restricts MuERVL-marked 2-cell-like state in embryonic stem cells.Stem cell reports · 2022Article
- Identification ofGenes · 2022Article
- FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.Cellular and molecular life sciences : CMLS · 2021Article
- Retinoic acid induces NELFA-mediated 2C-like state of mouse embryonic stem cells associates with epigenetic modifications and metabolic processes in chemically defined media.Cell proliferation · 2021Article
- Retinoic acid signaling is critical during the totipotency window in early mammalian development.Nature structural & molecular biology · 2021Article
- ZSCAN4EMBO reports · 2020Article
- A novel member of Prame family, Gm12794c, counteracts retinoic acid differentiation through the methyltransferase activity of PRC2.Cell death and differentiation · 2020Article
- Topographic Cues Impact on Embryonic Stem Cell Zscan4-Metastate.Frontiers in bioengineering and biotechnology · 2020Article
- Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells.International journal of stem cells · 2019Article
- Retinoic Acid Induces Embryonic Stem Cells (ESCs) Transition to 2 Cell-Like State Through a Coordinated Expression ofFrontiers in cell and developmental biology · 2019Article
- Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage.Stem cell research · 2018Article
- Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells.Cell death & disease · 2018Article
- Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies.Stem cells international · 2018Review
- Candidate genes and pathways downstream of PAX8 involved in ovarian high-grade serous carcinoma.Oncotarget · 2016Article
- Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotency confers Embryonic Stem Cells (ESCs) the ability to differentiate in ectoderm, endoderm, and mesoderm derivatives, producing the majority of cell types. Although the majority of ESCs divide without losing pluripotency, it has become evident that ESCs culture consists of multiple cell populations with different degrees of potency that are spontaneously induced in regular ESC culture conditions. Zscan4, a key pluripotency factor, marks ESC subpopulation that is referred to as high-level of pluripotency metastate. Here, we report that in ESC cultures treated with retinoic acid (RA), Zscan4 ESCs metastate is strongly enhanced. In particular, we found that induction of Zscan4 metastate is mediated via RA receptors (RAR-alpha, RAR-beta, and RAR-gamma), and it is dependent on phosphoinositide-3-kinase (PI3K) signaling. Remarkably, Zscan4 metastate induced by RA lacks canonical pluripotency genes Oct3/4 and Nanog but retained both self-renewal and pluripotency capabilities. Finally we demonstrated that the conditional ablation of Zscan4 subpopulation is dispensable for both endoderm and mesoderm but is required for ectoderm lineage. In conclusion, our research provides new insights about the role of RA signaling during ESCs high pluripotency metastate fluctuation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.