Evidence map›Paper›PMID 26840058›Full record

ArticlePloS one2016

Adipose-Derived Mesenchymal Stem Cells Restore Impaired Mucosal Immune Responses in Aged Mice.

Kazuyoshi Aso, Akitoshi Tsuruhara, Kentaro Takagaki, Katsuyuki Oki, Megumi Ota, Yasuhiro Nose, Hideki Tanemura, Naoki Urushihata, Jinichi Sasanuma, Masayuki Sano and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kazuyoshi AsoDepartment of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL, United States of America.
Akitoshi TsuruharaDepartment of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL, United States of America.
Kentaro TakagakiBioMimetics Sympathies Inc., Tokyo, Japan.
Katsuyuki OkiBioMimetics Sympathies Inc., Tokyo, Japan.
Megumi OtaBioMimetics Sympathies Inc., Tokyo, Japan.
Yasuhiro NoseBioMimetics Sympathies Inc., Tokyo, Japan.
Hideki TanemuraBioMimetics Sympathies Inc., Tokyo, Japan.
Naoki UrushihataBioMimetics Sympathies Inc., Tokyo, Japan.
Jinichi SasanumaDepartment of Neurosurgery, Shinyurigaoka General Hospital, Kawasaki, Japan.
Masayuki SanoSunfield Clinic, Koto-ku, Tokyo, Japan.
Atsuyuki HiranoSunfield Clinic, Koto-ku, Tokyo, Japan.
Rio AsoDepartment of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL, United States of America.
Jerry R McGheeDepartment of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL, United States of America.
Kohtaro FujihashiDepartment of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown that adipose-derived mesenchymal stem cells (AMSCs) can differentiate into adipocytes, chondrocytes and osteoblasts. Several clinical trials have shown the ability of AMSCs to regenerate these differentiated cell types. Age-associated dysregulation of the gastrointestinal (GI) immune system has been well documented. Our previous studies showed that impaired mucosal immunity in the GI tract occurs earlier during agingthan is seen in the systemic compartment. In this study, we examined the potential of AMSCs to restore the GI mucosal immune system in aged mice. Aged (>18 mo old) mice were adoptively transferred with AMSCs. Two weeks later, mice were orally immunized with ovalbumin (OVA) plus cholera toxin (CT) three times at weekly intervals. Seven days after the final immunization, when fecal extract samples and plasma were subjected to OVA- and CT-B-specific ELISA, elevated levels of mucosal secretory IgA (SIgA) and plasma IgG antibody (Ab) responses were noted in aged mouse recipients. Similar results were also seen aged mice which received AMSCs at one year of age. When cytokine production was examined, OVA-stimulated Peyer's patch CD4+ T cells produced increased levels of IL-4. Further, CD4+ T cells from the lamina propria revealed elevated levels of IL-4 and IFN-γ production. In contrast, aged mice without AMSC transfer showed essentially no OVA- or CT-B-specific mucosal SIgA or plasma IgG Ab or cytokine responses. Of importance, fecal extracts from AMSC transferred aged mice showed neutralization activity to CT intoxication. These results suggest that AMSCs can restore impaired mucosal immunity in the GI tract of aged mice.

Indexed as

Immunity, MucosalAdipose TissueAgingAllograftsAnimalsCD4-Positive T-LymphocytesCholera ToxinFemaleImmunoglobulin A, SecretoryInterferon-gammaInterleukin-4MaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMicePeyer's PatchesCholera ToxinImmunoglobulin A, SecretoryInterferon-gammaInterleukin-4

Identifiers

PMID26840058
PMCPMC4740412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.