ArticleeNeuro
Climbing Fiber Regulation of Spontaneous Purkinje Cell Activity and Cerebellum-Dependent Blink Responses(1,2,3).
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Effect of taVNS on the Cerebello-Thalamo-Cortical Pathway: a TMS Study.Cerebellum (London, England) · 2024Trial
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Effects of working memory load and CS-US intervals on delay eyeblink conditioning.NPJ science of learning · 2023Article
- Diverse role of NMDA receptors for dendritic integration of neural dynamics.PLoS computational biology · 2023Article
- Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat.Annals of neurology · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Cerebellar learning using perturbations.eLife · 2018Article
- In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model.Cerebellum (London, England) · 2018Article
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Electrophysiological Correlates of Blast-Wave Induced Cerebellar Injury.Scientific reports · 2018Article
- A Longer Interstimulus Interval Yields Better Learning in Adults and Young Adolescents.Frontiers in behavioral neuroscience · 2018Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active. The cerebellar output will, therefore, depend on how input is integrated into this spontaneous activity. It has been shown that input from climbing fibers originating in the inferior olive controls the spontaneous activity in Purkinje cells. While blocking climbing fiber input to the Purkinje cells causes a dramatic increase in the firing rate, increased climbing fiber activity results in reduced Purkinje cell activity. However, the exact calibration of this regulation has not been examined systematically. Here we examine the relation between climbing fiber stimulation frequency and Purkinje cell activity in unanesthetized decerebrated ferrets. The results revealed a gradual suppression of Purkinje cell activity, starting at climbing fiber stimulation frequencies as low as 0.5 Hz. At 4 Hz, Purkinje cells were completely silenced. This effect lasted an average of 2 min after the stimulation rate was reduced to a lower level. We also examined the effect of sustained climbing fiber stimulation on overt behavior. Specifically, we analyzed conditioned blink responses, which are known to be dependent on the cerebellum, while stimulating the climbing fibers at different frequencies. In accordance with the neurophysiological data, the conditioned blink responses were suppressed at stimulation frequencies of ≥4 Hz.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.