Evidence map›Paper›PMID 26839846›Full record

ArticleScientia pharmaceutica

Physicochemical and Microbiological Stability of the Extemporaneous Sildenafil Citrate Oral Suspension.

Attawadee Sae Yoon, Somchai Sawatdee, Chuthamas Woradechakul, Kridsada Sae Chee, Apichart Atipairin

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In one paragraph

Article in Scientia pharmaceutica. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Attawadee Sae YoonSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand; Drug and Cosmetic Research and Development Unit, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.
Somchai SawatdeeSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand; Drug and Cosmetic Research and Development Unit, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.
Chuthamas WoradechakulSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.
Kridsada Sae CheeSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.
Apichart AtipairinSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand; Drug and Cosmetic Research and Development Unit, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sildenafil is a potent and selective phosphodiesterase-5 inhibitor that is effectively used in the treatment of pulmonary arterial hypertension. In several countries, hospital pharmacists prepare the drug in an extemporaneous liquid preparation as there are no liquid formulations available for pediatric and adult uses. The purpose of this study was to evaluate the stability of an extemporaneous sildenafil citrate oral suspension for 90 days, according to the ASEAN guideline on stability studies of drug products. The results showed that the preparation was a white suspension with a sweet taste. It was a viscous and weakly acidic mixture with pseudoplastic behavior. The drug content was in the range between 99.23% and 102.23%, and the microbial examination met the general requirements throughout the study period. Therefore, the extemporaneously compounded sildenafil suspensions were physically, chemically, and microbiologically stable for at least 90 days when stored at 30° and 40°C. Furthermore, the in-use stability study showed that the preparations had acceptable attributes at least 14 days after the first-time use. This might provide an alternative option when the commercial suspension is unavailable.

Indexed as

ASEAN guidelineExtemporaneous preparationSildenafilStability studySuspension

Identifiers

PMID26839846
PMCPMC4727739

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