ArticlePeerJ2016
Impact of demographics on human gut microbial diversity in a US Midwest population.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Trial
- Article
- Gut microbiota-derived 4-hydroxyphenylacetic acid (4-HPAA) inhibits weight gain and is negatively associated with childhood obesity.Translational pediatrics · 2025Article
- Potential roles of cigarette smoking on gut microbiota profile among Chinese men.BMC medicine · 2025Article
- Article
- Understanding the impact of the gut microbiome on opioid use disorder: Pathways, mechanisms, and treatment insights.Microbial biotechnology · 2024Review
- Maternal Body Mass Index Associates with Prenatal Characteristics and Fecal Microbial Communities.Nutrients · 2024Observational
- Altered interaction network in the gut microbiota of current cigarette smokers.Engineering microbiology · 2024Article
- Cigarette Smoking and Human Gut Microbiota in Healthy Adults: A Systematic Review.Biomedicines · 2022Review
- Dietary fiber and probiotics based on gut microbiota targeting for functional constipation in children with cerebral palsy.Frontiers in pediatrics · 2022Article
- Recent developments in cancer research: Expectations for a new remedy.Annals of gastroenterological surgery · 2021Review
- Fecal Microbiota Transplantation during and Post-COVID-19 Pandemic.International journal of molecular sciences · 2021Review
- Article
- Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country.Scientific reports · 2021Article
- Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats.PloS one · 2021Article
- Circulating 16S RNA in Biofluids: Extracellular Vesicles as Mirrors of Human Microbiome?International journal of molecular sciences · 2020Review
- A gut microbiota score predicting acute graft-versus-host disease following myeloablative allogeneic hematopoietic stem cell transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The clinical utility of microbiome biomarkers depends on the reliable and reproducible nature of comparative results. Underappreciation of the variation associated with common demographic, health, and behavioral factors may confound associations of interest and generate false positives. Here, we present the Midwestern Reference Panel (MWRP), a resource for comparative gut microbiome studies conducted in the Midwestern United States. We analyzed the relationships between demographic and health behavior-related factors and the microbiota in this cohort, and estimated their effect sizes. Most variables investigated were associated with the gut microbiota. Specifically, body mass index (BMI), race, sex, and alcohol use were significantly associated with microbial β-diversity (P < 0.05, unweighted UniFrac). BMI, race and alcohol use were also significantly associated with microbial α-diversity (P < 0.05, species richness). Tobacco use showed a trend toward association with the microbiota (P < 0.1, unweighted UniFrac). The effect sizes of the associations, as quantified by adjusted R(2) values based on unweighted UniFrac distances, were small (< 1% for all variables), indicating that these factors explain only a small percentage of overall microbiota variability. Nevertheless, the significant associations between these variables and the gut microbiota suggest that they could still be potential confounders in comparative studies and that controlling for these variables in study design, which is the main objective of the MWRP, is important for increasing reproducibility in comparative microbiome studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.