Evidence map›Paper›PMID 26839664›Full record

ReviewThe Korean journal of pain2016

Neural Ablation and Regeneration in Pain Practice.

Eun Ji Choi, Yun Mi Choi, Eun Jung Jang, Ju Yeon Kim, Tae Kyun Kim, Kyung Hoon Kim

2 registry-linked trialsOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Korean journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04542798 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Central Sensitization and Aberrant Nerve Sprouting Possible Explanations for RFA Failure of MBDR in CLBP of FJ Origin: CRF Versus WCRF or PRF-DRG Randomized Clinical Trial

TypeinterventionalSponsorHospital General Universitario de ValenciaRan2020 to 2024Enrolled80ConditionsLow Back Pain, Recurrent, Neuropathic Pain, Facet Joint Pain, Central SensitisationArmsRadiofrequency COSMAN
NCT06204874 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Pulsed Radiofrequency Ablation of the Superior Hypogastric Plexus for Treatment of Bladder Pain Syndrome: A Case Series

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2024 to 2026Enrolled5ConditionsBladder Pain SyndromeArmsPulsed radiofrequency ablation
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 126 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eun Ji ChoiDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Yun Mi ChoiDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Eun Jung JangDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Ju Yeon KimDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Tae Kyun KimDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Kyung Hoon KimDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Pusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nerve block is an effective tool for diagnostic and therapeutic methods. If a diagnostic nerve block is successful for pain relief and the subsequent therapeutic nerve block is effective for only a limited duration, the next step that should be considered is a nerve ablation or modulation. The nerve ablation causes iatrogenic neural degeneration aiming only for sensory or sympathetic denervation without motor deficits. Nerve ablation produces the interruption of axonal continuity, degeneration of nerve fibers distal to the lesion (Wallerian degeneration), and the eventual death of axotomized neurons. The nerve ablation methods currently available for resection/removal of innervation are performed by either chemical or thermal ablation. Meanwhile, the nerve modulation method for interruption of innervation is performed using an electromagnetic field of pulsed radiofrequency. According to Sunderland's classification, it is first and foremost suggested that current neural ablations produce third degree peripheral nerve injury (PNI) to the myelin, axon, and endoneurium without any disruption of the fascicular arrangement, perineurium, and epineurium. The merit of Sunderland's third degree PNI is to produce a reversible injury. However, its shortcoming is the recurrence of pain and the necessity of repeated ablative procedures. The molecular mechanisms related to axonal regeneration after injury include cross-talk between axons and glial cells, neurotrophic factors, extracellular matrix molecules, and their receptors. It is essential to establish a safe, long-standing denervation method without any complications in future practices based on the mechanisms of nerve degeneration as well as following regeneration.

Indexed as

AxonChemical NeurolysisDenervationElectromagnetic fieldMyelinNerve degenerationNerve regenerationPeripheral nerve injuryPulsed radiofrequency treatmentWallerian degeneration

Identifiers

PMID26839664
PMCPMC4731549
OpenAlexW2262911726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.