Evidence map›Paper›PMID 26839649›Full record

ReviewWorld journal of gastrointestinal endoscopy2016

Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection.

Nikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastrointestinal endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Peroral endoscopic tumor resection of recurrent hypopharyngeal fibrovascular polyp.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025
    Review
  4. Article
  5. Submucosal tunneling endoscopic full-thickness resection for management of a rare case of esophageal GI stromal tumor.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Consensus on the digestive endoscopic tunnel technique.World journal of gastroenterology · 2019
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Endoscopic Management of Benign Esophageal Ruptures and Leaks.Current treatment options in gastroenterology · 2017
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Nikolas EleftheriadisNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Haruhiro InoueNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Haruo IkedaNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Manabu OnimaruNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Roberta MaselliNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Grace SantiNikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan.
Metropolitan Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroral endoscopic myotomy (POEM) is an innovative, minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy (LHM), not only for all types of esophageal achalasia [classical (I), vigorous (II), spastic (III), Chicago Classification], but also for advanced sigmoid type achalasia (S1 and S2), failed LHM, or other esophageal motility disorders (diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction (EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection (POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors (submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives.

Indexed as

AchalasiaEndoFLIPEndoscopic submucosal dissectionHeller myotomyLaparoscopic myotomyLESMinimally invasive surgeryNatural orifice transluminal endoscopy surgeryPer-oral endoscopic myotomyPeroral endoscopic tumorectomySubmucosal endoscopyTransluminal technique

Identifiers

PMID26839649
PMCPMC4724034
OpenAlexW2412232200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.