ArticleJournal of biological engineering2016
End-to-end automated microfluidic platform for synthetic biology: from design to functional analysis.
Article in Journal of biological engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- DecipheringMicroorganisms · 2026Review
- Improving engineered biological systems with electronics and microfluidics.Nature biotechnology · 2025Review
- Leveraging CRISPR-Cas-Enhanced Isothermal Amplification Tools for Quick Identification of Pathogens Causing Livestock Diseases.Current microbiology · 2025Review
- Controlling Biomedical Devices Using Pneumatic Logic.Annals of biomedical engineering · 2025Article
- BioNexusSentinel: a visual tool for bioregulatory network and cytohistological RNA-seq genetic expression profiling within the context of multicellular simulation research using ChatGPT-augmented software engineering.Bioinformatics advances · 2024Article
- Designing artificial synthetic promoters for accurate, smart, and versatile gene expression in plants.Plant communications · 2023Review
- Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid.Journal of biological engineering · 2022Review
- Hardware, Software, and Wetware Codesign Environment for Synthetic Biology.Biodesign research · 2022Review
- Acoustofluidic medium exchange for preparation of electrocompetent bacteria using channel wall trapping.Lab on a chip · 2021Article
- Process Variability in Top-Down Fabrication of Silicon Nanowire-Based Biosensor Arrays.Sensors (Basel, Switzerland) · 2021Review
- Article
- Characterization and Optimization of Isotachophoresis Parameters for Pacific Blue Succinimidyl Ester Dye on a PDMS Microfluidic Chip.Micromachines · 2020Article
- Rapid, robust plasmid verification by de novo assembly of short sequencing reads.Nucleic acids research · 2020Article
- The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology.Journal of medicinal chemistry · 2020Review
- Beyond natural: synthetic expansions of botanical form and function.The New phytologist · 2020Review
- Article
- The Oxygen Release Instrument: Space Mission Reactive Oxygen Species Measurements for Habitability Characterization, Biosignature Preservation Potential Assessment, and Evaluation of Human Health Hazards.Life (Basel, Switzerland) · 2019Article
- The Usual Suspects 2019: of Chips, Droplets, Synthesis, and Artificial Cells.Micromachines · 2019Review
- Improving Reproducibility in Synthetic Biology.Frontiers in bioengineering and biotechnology · 2019Article
- DNA assembly with error correction on a droplet digital microfluidics platform.BMC biotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSynthetic biology aims to engineer biological systems for desired behaviors. The construction of these systems can be complex, often requiring genetic reprogramming, extensive de novo DNA synthesis, and functional screening.
resultsHerein, we present a programmable, multipurpose microfluidic platform and associated software and apply the platform to major steps of the synthetic biology research cycle: design, construction, testing, and analysis. We show the platform's capabilities for multiple automated DNA assembly methods, including a new method for Isothermal Hierarchical DNA Construction, and for Escherichia coli and Saccharomyces cerevisiae transformation. The platform enables the automated control of cellular growth, gene expression induction, and proteogenic and metabolic output analysis.
conclusionsTaken together, we demonstrate the microfluidic platform's potential to provide end-to-end solutions for synthetic biology research, from design to functional analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.